_临床医学实验室生物参考区间的建立.pdfVIP

2008 7 23 4 　LaboraoryMedicine, July2008, Vol23.No4. ·421 · :1673 -8640 (2008)04 -042 1-04　　　:R446.1　　　:A 陈桂山, 　杨有业, 　梁锦胜, 　温冬梅 (, 528403 ) 　　:　(TC)、(HDL-C)2 , 。　 ISO15189:2003 (E)《———》 (NCCLS)C2 8-A2, 、 , , , 120 , 。　TC, ;HDL-C , , , 0.82 ～ 1.82 mmol/L、 0.89 ～ 1.97mmol/L。　 、、、 , , 。 :;; 　　Esablishmenofbiologyreferenceinervalinclinicalmedicinelaboraory.　CHENGuishan, YANGYouy,e LIANGJinsheng, WENDongme.i(DeparmenofClinicalLaboraory, Zhongshanciypeople′shospia,lGuangdong Zhongshan528403, China) 　　Absrac:Objecive　Toexploreasuiablemehodforourlaboraoryoesablishhebiologicalreferenceinerva,l akingoalcholeserol(TC)andhigh-densiylipoproeins-choleserol(HDL-C)asexamples.Mehods　Accordingo heiemsofISO15189:200 3(E)hemedicinelaboraory——— Thequaliyandheabiliyofspecia-lpurposeandhe mehodsrecommendedby(NCCLS)C28-A2, weverifiedTCandHDL-Chroughessbymeansofinervalseiherquo- edfromperiodicalsorhemanufacoryinsrucion,sorransferredfromohermedicinelaboraorie.sAproperbiology referenceinervalwillbeesablishedagainbycollecing120 healhypersonsasreference.Resuls　TCpassedhees andremainsvalid, whileHDL-Cfailedheverificaionandneedoesablishanewbiologyreference.Thenewinerval ofHDL-Cwas0.82-1.82 mmol/Lformaleand0.89-1.97 mmol/Lforfemale.Conclusions　Themehodofesablis- hingbiologicalreferenceinervalusedinoursudycanguaraneeheinervalsofesingiemsinmanywaysreliabl,eaccu- ra,escienificandpracica.lIcansaisfyheclinicalrequiremenandisworhobeusedinohermedicinelaboraory. 　　Keywords:Biologyreferenceinerva;lClinicallaboraory;Esablishemen 　　 , [1] 。 、”。 , ISO15189 NCCLSC28-A2 [2] 。 ,、