精神分裂症患者富马酸喹硫平血药浓度测定及其及临床效应的相关性.pdfVIP

精神分裂症患者富马酸喹硫平血药浓度测定及其与临床效应的相关性 250012) 摘要：目的建立反相高效液相色谱法测定精神分裂症患者富马酸喹硫平血药浓度的方法学，探讨其血药浓度与患者年龄、 性别、服药剂量及临床效应的关系。方法采用高效液相色谱法测定76例单一服用富马酸喹硫平精神分裂症住院患者治疗 前及治疗后第2，4，6周血药浓度，并进行BPRS量表评定及相关性分析。结果富马酸喹硫平血药浓度在50～500ng·mL_1内 有良好线性关系(r=0．9850)。日剂量在50～450 rag内血药浓度随剂量的增大而升高，但与服药患者年龄、性别无显著相关 性。血药浓度在126。350 ng·mL-1范围内临床效果较好。结论测定方法简便、准确、专一性强，可用于富马酸喹硫平血药浓 度监测。富马酸喹硫平治疗窗浓度为126—350ng·mL～。 关键词：富马酸喹硫平；血药浓度；高效液相色谱法 中图分类号：R969 文献标识码：A 文章编号：1001—2494(2004)12—0928—03 Y沦tlllnconcentrationandclinical of fumaratein wiUl on Study responsequetiapine patientsschizophrenia FU MentalHealth Gui—hual，TANG Center，Jinan250014，Ch／一 Chong．min91，ZHANG Mao．qinl，GUORui．chen2。(1．Shandong ofClinical University，Jinan250012，Ch／na) ／26；2．DepartmentPharmacology，QiluHospital，Shandong ToestablishaRP-HPICmethodforthedeterminationof fumarateconcentrationin with ABSTRACT：OBJECrIVE quefiapine patients serum clinical AHPICmethodwasusedtode— to the betweenconcentrationand 8(3hizophrenia．andstudyrelationship response．ⅣⅡ门lK嬲 tennine fumarateconcentration．Bloodwerecollectedin76 beforeorattheendof weeksof quetiapine samples schizophreniainpatients 2，4，6 fmnaratetreatmentandthe WasmeasuredBPRS．RESULTS’nlestandardcurvewaslinearoverthe of therapeutic quetiapine efficacy by range in serumconcentrationswere increasedwith dosein 50～500 of fumaratesertlln(r=0．9850)．’The ng．InL。1quetiapine proportionally daily the of50～450 no