压片机充填过程影响因素的研究进展.pdfVIP

610 Chinese Journal of Pharmaceuticals 2010, 41 8 · · 中国医药工业杂志 ( ) 制药装备与包装 压片机充填过程影响因素的研究进展 * 虞雅萍，陈 岚 ，施昊韫 200093 (上海理工大学医疗器械与食品学院，上海 ) 摘要：压片机充填过程分为重力充填、强迫式充填和附加的吸入式充填，充填过程粉末颗粒的流动性决定片重差异。本 文从实验研究和数值计算两方面综述影响以上几种充填过程粉末颗粒流动性的重要因素，包括粉末颗粒性质、充填环 境、机器结构及运行参数。 关键词：压片机；充填过程；粉末颗粒性质；机器结构；运行参数；综述 TQ460.5 A 1001-8255 2010 08-0610-05 中图分类号： 文献标志码： 文章编号： ( ) Progress of The Influencing Factors on Die Filling Process of Tablet Press YU Yaping, CHEN Lan*, SHI Haoyun School of Medical Instrument and Food Engineering, University of Shanghai for Science Technology, Shanghai 200093 ( ) ABSTRACT : The die filling process of tablet press is generally classified in gravity filling, forced filling and additional suction filling. The tablet weight variation is mainly effected by the flowability of filling powder. This paper reviews the important factors which influence the powder flowability in the three die filling processes mentioned above. These factors include material properties, environmental conditions, construction of tablet press and operational parameters. Key Words: tablet press; die filling process; material properties; construction of tablet press; operational parameters; review 片剂是药物最常见剂型之一，压片过程与粉末 充填过程粉末颗粒的流动性受以下因素综合影 冶金以及陶瓷工业类似，分为充填、