医用多糖止血愈合海绵对小型猪股动脉出血模型的止血作用研究.pdf

Med J Chin PLA, Vol. 40, No. 3, March 1, 2015 　245 论　著 医用多糖止血愈合海绵对小型猪股动脉出血模型的止血作 用研究 徐红霞，于燕，王晓阳，姜毅 [摘要]　目的　研究医用多糖止血愈合海绵(MP)在小型猪股动脉出血模型中的止血作用。方法　采用小型猪32只 制作股动脉出血模型后随机分为4组(n=8) ，分别采用MP 、羧甲基纤维素(CMC)、明胶海绵(GS)和医用纱布(MG)进行 创面外敷止血，观察各组的止血时间、失血量及小型猪生命体征。结果　建立小型猪股动脉出血模型后，各组动物平 均动脉压无明显差异。MP组、CMC组、GS组的止血时间及失血量均明显低于MG组(P 0.01) ，且CMC组的止血效果优 于MP组和GS组，而MP组和GS组的止血效果相似。结论　MP 、CMC敷料对小型猪股动脉止血效果确切，与GS相似或 略优于GS 。 [关键词]　透明质酸；羧甲基纤维素；明胶海绵，吸收性；止血 [中图分类号]　R605.972　　　　[文献标志码]　A　　　　[文章编号]　0577-7402(2015)03-0245-03 [DOI]　10.11855/j.issn.0577-7402.2015.03.15 Hemostatic effect of a medical polysaccharide hemostatic healing sponge on hemostasis of bleeding from femoral artery in pigs 1 1 2 3* XU Hong-xia , YU Yan , WANG Xiao-yang , JIANG Yi 1 2 Department of Burns and Plastic Surgery, Department of R espiratory Medicine, Navy General Hospital, Beijing 100048, China 3 Clinic of Political Department of Shenyang Command, Shenyang 110032, China * Corresponding author, E-mail: j iangyi1974@ [Abstract]　Objective　To study the effect of polysaccharide hemostatic healing sponge in controlling bleeding from femoral artery in miniature swines. Methods　Thirty two miniature pigs were used to reproduce femoral artery hemorrhage model and then divided equally into four groups, and bleeding from femoral artery was treated by Medical Polysaccharide Hemost atic Healing Sponge (MP), carboxymethyl cellulose (CMC), gelatin sponge (GS) or medical gauze (MG), respectively. Hemostasis time, blood loss and vital signs of these pigs were observed and recorded. Results　There were no group differences in mean arterial pressure. Hemostasis time was earlier and blood loss was less in MP, CMC and GS g