膜联蛋白a2 的结构、功能及其在疾病中的研究进展 - 中国现代应用药学.pdfVIP

·综 述 · 膜联蛋白 A2 的结构、功能及其在疾病中的研究进展  林枝云 1 ，宋英 1 ，何巍 2 ，戴海斌 2*(1.浙江工业大学药学院，杭州 310005 ；2.浙江大学医学院附属第二医院，杭州 310009) 摘要：膜联蛋白 A2 是一种钙离子介导的磷脂结合特性的蛋白质，属于膜联蛋白家族成员，广泛分布于各种真核细胞膜、 细胞质和细胞外液，主要表达在血管内皮细胞、单核细胞、巨噬细胞、树突状细胞、滋养层细胞、上皮细胞、肿瘤细胞 等细胞中。其功能主要是参与膜转运及膜表面一系列依赖于钙调蛋白的活动，包括胞吐作用中的膜融合、囊泡运输、细 胞黏附、细胞增殖、凋亡、复制、信号传导以及离子通道的形成，许多疾病及体内调控都与膜联蛋白 A2 有关。根据最 近的文献报道，对膜联蛋白 A2 的结构、功能及其在疾病中的研究进展作一综述。 关键词：膜联蛋白 A2 ；功能；进展 中图分类号：R963 文献标志码：A 文章编号：1007-7693(2016)10-1350-05 DOI: 10.13748/ki.issn1007-7693.2016.10.031 Structure and Function of Annexin A2 and it’s Research Progress in Diseases 1 1 2 2* LIN Zhiyun , SONG Ying , HE Wei , DAI Haibin (1.College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310005, China; 2.Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China) ABSTRACT: Annexin A2 is a calciumion-induced phospholipid binding properties of proteins, belonging to members of the family of membrane proteins, and it is widely distributed in all kinds of eukaryotic cell membrane, cytoplasm and tissue fluid. It is mainly expressed in human endothelial cells, monocytes, macrophages, dendritic cells, trophoblast cells, epithelial cells and tumor cells. Annexin A2 has various functions, which is mainly involved in membrane transport and a series activity which is depends on the activity of calmodulin in the surface of cell membrane, such as cell spit role in membrane fusion, vesicle transportation, cell adhesion, cell proliferation, apoptosis, replication, signal conduction and ion channel formation, many diseases and in vivo regulation are related to Annexin A2. According to recent reports in the literatures, a summarize about the structure and function of Annexin A2 in diseases will be writed. KEY WORDS: annexin A2; function; pro