植物多糖通过nf-κb信号通路对巨噬细胞的免疫调节作用 - 食品科学.pdf

288 2015, Vol.36, No.23 食品科学 ※专题论述 植物多糖通过NF-κB信号通路对巨噬细胞的 免疫调节作用研究进展 1 1 1 2 1,3,* 陈金龙，张月巧，袁 娅 ，吴素蕊，明 建 （1.西南大学食品科学学院，重庆 400715 ；2. 中华全国供销合作总社昆明食用菌研究所，云南 昆明 650223 ； 3.西南大学 国家食品科学与工程实验教学中心，重庆 400715 ） 摘  要：植物多糖具有一定的免疫调节功能，作为免疫调节剂已广泛应用于医疗和保健食品行业。核转录因子κB nuclear factor kappa B NF-κB （ ， ）是一种可以调控基因转录的核因子，对巨噬细胞内部的多种基因都有调控作用， 许多研究表明植物多糖主要通过NF-κB信号传导通路诱导巨噬细胞发生免疫应答。本文介绍了NF-κB信号通路的组 成和调节以及巨噬细胞表面介导植物多糖的受体活化NF-κB 的机理，为深入研究植物多糖免疫调节功能提供参考。 关键词：植物多糖；核转录因子κB ；信号通路；巨噬细胞；免疫调节 Progress in Research on Immune-Regulatory Effects of Plant Polysaccharides on Macrophages through NF-κB Signaling Pathway 1 1 1 2 1,3,* CHEN Jinlong , ZHANG Yueqiao , YUAN Ya , WU Surui , MING Jian (1. College of Food Science, Southwest University, Chongqing 400715, China; 2. Kunming Edible Fungi Institute of All China Federation of Supply and Marketing Cooporatives, Kunming 650223, China; 3. National Food Science and Engineering Experimental Teaching Center, Southwest University, Chongqing 400715, China) Abstract: Plant polysaccharides have immune-regulatory function and can be widely used in medical and health food industries as immunomodulatory agents. Nuclear factor kappa B (NF-κB), as one of the nuclear factors regulating gene transcription, plays a critical role in the regulation of multiple genes in macrophages. Many studies have shown that plant polysaccharides induce immune response of macrophages through NF-κB signaling pathway. This review describes the composition and regulation of NF-κB signaling pathway as wel