副溶血弧菌毒力因子及致病机理的研究进展 - 食品科学.pdf

216 2015, Vol.36, No.07 食品科学 ※专题论述 副溶血弧菌毒力因子及致病机理的研究进展 1 1 2 3 3 1 1 1 1,* 张德福 ，付绪磊，张 明，杨文慧，杨慧盈，汤轶伟，高 雪，徐永霞，励建荣 （1.渤海大学食品科学与工程学院，辽宁省食品安全重点实验室，辽宁 锦州  121013；2.渤海大学新能源学院， 辽宁 锦州  121013；3.军事医学科学院微生物流行病研究所，病原微生物生物安全国家重点实验室，北京  100071） 摘  要：副溶血弧菌为一种嗜盐性革兰氏阴性短杆菌，是引发人食源性疾病的主要致病菌之一，主要分布在海洋环 境中。副溶血弧菌的毒力因子主要包括黏附因子、侵袭因子、溶血性毒素、尿素酶、脂多糖、外膜蛋白、蛋白酶、 Ⅲ型分泌系统和摄铁系统等。本文就副溶血弧菌的主要毒力因子及其致病机理的研究进展进行综述，可为进一步研 究该菌的分子致病机理、制定快速精确的检测方法等提供参考。 关键词：副溶血弧菌；毒力因子；致病机理；溶血素；Ⅲ型分泌系统 Recent Progress in Research on Vibrio parahaemolyticus Virulence Factors and Pathogenic Mechanism 1 1 2 3 3 1 1 1 1,* ZHANG Defu , FU Xulei , ZHANG Ming , YANG Wenhui , YANG Huiying , TANG Yiwei , GAO Xue , XU Yongxia , LI Jianrong (1. Food Safety Key Laboratory of Liaoning Province, College of Food Science and Engineering, Bohai University, Jinzhou 121013, China; 2. College of New Energy, Bohai University, Jinzhou 121013, China; 3. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China) Abstract: Vibrio parahaemolyticus is one of the key foodborne pathogens and its virulence factors include adherence factors, invasiveness factors, hemolysins, urease, lipopolysaccharide, outer membrane proteins, type Ⅲ secretion system and ferric uptake system. In this article, V. parahaemolyticus virulence factors and its pathogenic mechanism are summarized, which will hopefully provide references for further research of the molecular pathogenesis, and rapid and accurate detection of V. parahaemolyticus. Key words: Vibrio parahaemolyticus; virulence factors; pathogenesis; hemolysin; type Ⅲ secretion system 中图分类号：TS201.6