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Clinical reviews in allergy and immunology Series editors: Donald Y. M. Leung, MD, PhD, and Dennis K. Ledford, MD Histamine and H -antihistamines: Celebrating a century of 1 progress F. Estelle R. Simons, MD, FRCPC,a and Keith J. Simons, PhDb Winnipeg, Manitoba, Canada INFORMATION FOR CATEGORY 1 CME CREDIT Credit can now be obtained, free for a limited time, by reading the review AAAAI designates these educational activities for a maximum of 1 AMA articles in this issue. Please note the following instructions. PRA Category 1 Credit. Physicians should only claim credit commensu- Method of Physician Participation in Learning Process: The core ma- rate with the extent of their participation in the activity. terial for these activities can be read in this issue of the Journal or online at the List of Design Committee Members: F. Estelle R. Simons, MD, JACI Web site: . The accompanying tests may only be sub- FRCPC, and Keith J. Simons, PhD mitted online at . Fax or other copies will not be accepted. Activity Objectives Date of Original Release: December 2011. Credit may be obtained for 1. To understand new insights into the mechanism of action of these courses until November 30, 2013. H1-antihistamines. Copyright Statement: Copyright 2011-2013. All rights reserved. 2. To know when it is appropriate to use H1-antihistamines. Overall Purpose/Goal: To provide excellent reviews on key aspects of 3. To list the adverse effects of H1-antihistamines. allergic disease to those who research, treat, or manage allergic disease. Target Audience: Physicians and researchers within the field of allergic Recognition of Commercial Support: This CME activity has not re- disease.