p62与蛋白降解途径的研究进展 - 生理学报.pdf

48 生理学报Acta Physiologica Sinica , February 25, 2015, 67(1): 48–58 DOI: 10.13294/j.aps.2015.0005 综 述 p62与蛋白降解途径的研究进展 1,2 1 1,* 刘诗濛 ，董越娟，刘彬 1 2 河南大学护理学院神经生物学研究所； 附属淮河医院消化内科，开封 475000 p62 (ubiquitin-proteasome system, UPS) - 摘 要： 是一种多功能泛素结合蛋白，参与泛素蛋白酶体系统 和自噬 溶酶体系统两种 p62 蛋白降解过程。 作为一种信号转导途径中的支架和适配子蛋白，其分子结构中的多个功能结构域可与其它蛋白质相互作 p62 用，介导多种细胞功能，特别是在细胞的选择性自噬和细胞抗氧化反应中发挥重要作用，因而 与许多疾病的发病机制密 p62 UPS 切相关。本文主要综述 的结构特征及其与 和自噬的相互关系，旨在为相关领域的研究提供参考。 关键词：p62 ；蛋白降解；泛素；蛋白酶体；自噬 中图分类号：R37 Progress of study on p62 and protein degradation pathways 1,2 1 1,* LIU Shi-Meng , DONG Yue-Juan , LIU Bin 1 2 Institute of Neurobiology, College of Nursing; Department of Gastroenterology, Huaihe Clinical College, Henan University, Kaifeng 475000, China Abstract: The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a compo- nent within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions. Importantly, p62 plays a critical role in cell’s selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives