循环系统学习资料-心血管系统疾病-2016整合课程.pdfVIP

心血管系统疾病 Diseases of Cardiovascular System 四川大学华西临床医学院 病理学教研室 庞 宗 国 2012年城市居民主要疾病死亡原因构成 死亡原因 死亡构成% 1 恶性肿瘤 26.81 2 心脏病 2 1.45 3 脑血管病 19.61 4 呼吸系统疾病 12.32 5 损伤及中毒 5.67 中国卫生统计年鉴 动脉粥样硬化 Atherosclerosis 冠心病 Coronary Heart Disease 高血压 Hypertension 风湿病 Rheumatism 感染性心内膜炎 Infective Endocarditis 心肌病 Cardiomyopathy 心肌炎 Myocarditis Arteriosclerosis “hardening of the arteries” • Arteriolosclerosis • Medial calcific sclerosis • Atherosclerosismost common DEFINITION Atherosclerosis is a degenerative disease of large and medium-sized arteries characterised by lipid deposition and fibrosis. Affects the large and medium-sized arteries Lesions comprise fatty streaks, fibrous plaque, atheromatous plaque and complicated lesions Major cause of organ ischaemia Basic Pathologic Changes Fatty Streak 脂 纹 Fibrous Plaque 纤维斑块 Atheromatous Plaque 粥样斑块 Complications 继发改变 Fatty Streaks Fatty streak Fibrous Plaque Histologic feature 1.Fibrous cap 2.foamy cells, Smooth muscle cells and inflammatory cells can be seen 3.The structures of media are basically complete. Atheromatous Plaque Gross view 1.Raised focal lesions with a soft, yellow grumous core of lipid and covered by a firm,gray fibrous cap. 2.Complications often can be seen Typical atheromatous lesion FIBROUS CAP (smooth muscle cells, macrophages, foam cells, lympho