《计算系统生物学导论》系统生物学导论-2012-4.pptVIP

Determining the tissue speci?city of human protein interactions We then used gene expression data (Su et al, 2004) to determine the cells and tissues of the human body in whicheach of these interactions can occur (Figure 1A). If two genes are co-expressed in a cell, then under some condition their products can physically interact in that cell. However, if two proteins are not expressed in a tissue, then the interaction cannot occur in this tissue. Tissue speci?c and recently evolved proteins make few protein interactions We ?nd that more tissue-speci?c proteins make fewer interactio