营养性贫血(英语).pptVIP

NUTRITIONAL IRON DEFICIENCY ANEMIA;CONTENTS;INTRODUCTION;Clinical characteristics ? iron stores ? serum iron ?hemoglobin concentration , hypochromic microcytic anemia, good response to iron therapy. 6mo to 3 yrs. Incidence ;IRON METABOLISM;Iron sources Hemoglobin iron Dietary iron;Dietary iron High in iron Red meat/ liver kidney/ oily fish Average iron Beans / fortified cereals/ dark green vegetables/ dried fruit/ nuts and seeds Poor in iron milk;Iron absorption general absorption 1-20% Meat/ fish/ chicken 10-25% Cereals/vegetables 1% Breast/cow’s milk 50%/10%;ABSORPTION TRANSPORT ;Ferritin;IRON METABOLISM;IRON METABOLISM;HEMATOLOGY/ONCOLOGY, CHILDREN’S HOSPITAL;Poor iron stores Premature birth Multiple birth /Low weight birth Cord blood Mother iron reserve overdevelop Poor dietary intake of iron* Blood loss and iron depletion;Poor iron stores Poor dietary intake of iron* Milk and cereals Factors influencing absorption Diarrhea and infection Overdevelop Blood loss and iron depletion; ETIOLOGY PATHOGENESIS; ETIOLOGY PATHOGENESIS; Pathogenesis iron ? + protoporphyrin IDA ? heme + globins hemoglobin?;Pathogenesis Hypochromic / microcytic anemia ID. Iron deficiency IDE. Iron deficiency erythropoiesis IDA. Iron deficiency anemia Enzymes Immune function Skin/mucosal;Features Age The onset of the IDA The degree of anemia;Pallor Extramedullary hematopoiesis Mild/ Severe condition Digestive system Cardiac function Neurology/ intellectual Immune function;IDA: microcytic/hypochromic + SI↓ Peripheral blood： Hemoglobin level RBC MCV 80fl, MCH 26ug, MCHC 0.31 Bone marrow Erythroid hyperplasia Stainable iron?;IDA: hypochromic/microtytic anemia+ SI↓ SI： 9-10.7umol/L (12.8-31.3umol/L) or 50-60ug/dl (75-175ug/dl ） TIBC： 62.7umol/L (350ug/dl) TS： 15% （30-50%） IDE: SF↓,FEP↑（0.9umol/L or 50ug/dl) ID： SF 12ug/L / marrow iron;HEMATOLOGY/O