2013.11.18 -- 李奇Selection and adaptation during metastatic cancer progression.pdfVIP

PERSPECTIVE doi:10.1038/nature12628 Selection and adaptation during metastatic cancer progression Christoph A. Klein1,2 Cancer is often regarded as a process of asexual evolution driven by genomic and genetic instability. Mutation, selection and adaptation are by convention thought to occur primarily within, and to a lesser degree outside, the primary tumour. However, disseminated cancer cells that remain after ‘curative’ surgery exhibit extre