基质金属蛋白酶7在胶质母细胞瘤中的表达及其与患者术后生.PDF

704 West China Medical Journal Vol.27 No.5 May 2012 2012 27 , , 华西医学 , （5） 论　著 基质金属蛋白酶7在胶质母细胞瘤中的表达及其 与患者术后生存期的关系 1 2 杨波 ，唐伏秋 【摘要】　目的　探讨胶质母细胞瘤中基质金属蛋白酶 7 （MMP-7 ）的表达及其与患者术后生存期之间相关性。 方法　采用免疫组织化学法检测 60 例胶质母细胞瘤组织标本中 MMP-7 的表达，统计分析其表达强弱与患者术 后生存期之间的关系。 结果　MMP-7 在胶质母细胞瘤中总表达率为 73.3% ，强表达组生存期明显短于弱表达组 （χ2=7.043 ，P=0.008 ）。结论　MMP-7 可以作为胶质母细胞瘤预后的重要因素之一。 【关键词】　胶质母细胞瘤；免疫组织化学；基质金属蛋白酶 7 【文献标识码】　A　　　 Expression of Matrix Metalloproteinase-7 in Glioblastoma Tissues and Its Relationship with Postoperative Survival　 YANG Bo1 2 , TANG Fu-qiu .　1. Department of Oncology; 2. Department of Second Cadre Ward; Wuhan General Hospital of Guangzhou Command PLA, Wuhan, Hubei 430070, P. R. China 【Abstract】 Objective To investigate the expression of matrix metalloproteinase-7 (MMP-7) in glioblastoma tissues and its relationship with postoperative survival. Methods　The expressions of MMP-7 in 60 cases of glioblastoma tissues were detected by using the two-step immunohistochemical staining method. The relationship between MMP-7 expression and postoperative survival was analyzed by statistical method. Results　The total rate of MMP-7 expression in glioblastoma patients was 73.3%. The postoperative survival in strong expression group was significantly shorter than that in weak expression group (χ2=7.043, P=0.008). Conclusion　The expression of MMP-7 might be an important prognostic factor associated postoperative survival in glioblastoma patients. 【Key words】　Glioblastoma; Immunohistochemistry; Matrix metalloproteinase-7 胶质母细胞瘤是星形细胞肿瘤中恶性程度最高 层粘连蛋白等多种细胞外基质，与多种恶性肿