组蛋白磷酸化修饰与精子发生 - researchgate.pdf

See discussions, stats, and author profiles for this publication at: /publication/262533224 [Histone phosphorylation and spermatogenesis] Article in Hereditas ( eijing) · March 2014 Source: PubMed CITATION READS 1 15 3 authors, including: Zhaohui Zhang Hebei University 5 PU LICATIONS 12 CITATIONS SEE PROFILE All content following this page was uploaded by Zhaohui Zhang on 13 April 2016. The user has requested enhancement of the downloaded file. Hereditas (Beijing) 2014 *, 36(*): 1―8 综 述 组蛋白磷酸化修饰与精子发生 1,2 1 1 , , 1. , 071002; 2. , 071000 组蛋白磷酸化是组蛋白氨基酸残基的磷酸化修饰, 是一类重要的翻译后修饰, 与有丝分裂和减数分裂的 染色质压缩、染色质功能调节、转录的激活与抑制、DNA 损伤修复以及物质代谢等多种机制相关。文章对国 内外近 10 年多种代表性生物精子发生(孢子形成) 的相关文献进行总结, 论述了组蛋白磷酸化在精子发生中调 控蛋白质作用因子的结合位点、调控减数分裂过程中的DNA 复制与重组、保障正确的染色质重塑、对减数分 裂后的成熟精子核的完全包装等重要功能。这些发现加深了人们对于组蛋白及其翻译后修饰在精子发生及分化 中作用的理解。 精子质量; 精子发生; 组蛋白磷酸化; 表观遗传 Histone phosphorylation and spermatogenesis Zhaohui Zhang 1,2, Xianjiang Kang 1, Shumei Mu 1 1. College of Life Science, Hebei University, Baoding 071000, China; 2. Department of Reproduction Medicine, Maternal and Babies Health Center, Baoding 071002, China Abstract: Histone phosphorylation is one of the most important post-translational modifications (PTMs) which play a key role in the chromatin remodeling process during spermatogenesis. Histone phosphorylation is related to distinct im- portant biological processes, such as mitotic/meiotic chromosome condensation, chromatin function regulation, transcrip-