β-catenin信号通路.pdfVIP

国际妇产科学杂志2015年 8月第 42卷第 4期 JlntObstetGynecol，August2015，Vo1．42，No．4 · 409· · 综 述 · 子宫内膜异位症干细胞与Wnt／6一catenin信号通路 刘君，赵志梅 ，夏天 ，么秀洁 摘【 要】子宫内膜异位症(EMs)因其具有侵袭、易复发等特点被称为类肿瘤性疾病。近年随着EMs病因学研究不 断深入，子宫内膜中存在干细胞且这些干细胞参与子宫内膜的周期性活动的观点得以提出并陆续被验证，进而EMs干 细胞学说逐渐得到认可。在干细胞研究中随着分子生物学方法的应用 ，证明了越来越多的基因和信号通路参与了干细胞 的周期性调节，其中Wnt／$一catenin信号通路是干细胞的重要通路之一。Wnt／13一catenin信号通路以其高度保守、结构复 杂性而在多种肿瘤的发生发展中通过影响干细胞增殖周期发挥作用 ，同时Wnt3／1一catenin信号通路参与调节子宫内膜干 细胞，这将为EMs的发生、发展及治疗提供新的思路。 【关键词】子宫内膜异位症；干细胞 ；信号传导；B—catenin EndometriosisStem CellsandWnt／13-cateninSignalingPathway LIUJun，ZHA0Zhi-mei，XIATiua ，YA0Xiu-jie．Tianjin UniversityofTraditionalChineseMedicine，Tianjin300193，China (LIUJun，YA0Xiu-jie)；DepartmentofInfertility，FirstTeaching HosptialofTianjinUnivers ofTraditionalChineseMedciine，Tianjin300193，China(ZHA0Zhi—mei，XIATian) Correspondingauthor：ZHA0Zhi-me i，E—mail：zhoozhim2OO3@aliyun．com A【bstract】Endometriosis(EMs)ischaracterizedasclassneoplasticdiseasebecauseofitsinvasiveness，easytorelapse andotherneoplasticdiseasescharacter．Inrecentyears，withthedevelopmentofEMsetiologystudy，theexistenceofstem cellsin theendometrium andthesestem cellsareinvolvedintheendometrialcyclicalactivitieshavebeenproposedandvalidated，and thenEMsstem celltheoryisgraduallybeingrecognized．Intheresearchofstem cellastheapplicationofmolecularbiology method，agrowingnumberofgenesandsignalingpathwaysinvolvedinstem cellsprovedtObetakepartinstem cellScyclical activity，ofwhichWnt／J3-cateninsignalingpathwayisoneofthemostimportantresearchpathwaysofstemcells．Wntd3一catenin signalingpathwayishighlyconserved in itsstructuralcomplexity in thedevelopmentofavarietyoftumorsbystem cell proliferationcycleplayarole，meanwhileWnt／13-cateninsignalingpathwayinvolvedinendometrialstemcellregulation，which wouldprovidenew ideasfortheoccurrence，developmentandtreatmentofendometriosis． K【eywords】Endometriosis；Stemcells；Signaltransduct