人参皂甙Rg3促进同系小鼠外周血干细胞移植后免疫恢复研究.pdf

2005 10 25 5 C in J Radiol Med Prot, October 2005, Vol 25, No. 5 431 + 3 Voermans C, Rood PML, Hordijk PL, et al. Ad esion molecules in- , CD34 , volved in transendot elial migration of uman ematopoietic progenitor cells. Stem Cells, 2000, 18: 435-443. + , , 4 Yong KL, Watts M, T omas NS, et al. Transmigration of CD34 Cells PKC, across specialized and nonspecialized endot elium requires prior activa- tion by growt factors and is mediated by PECAM-1 ( CD31) . Blood , , , 1998,91: 1196-1205. 5 Peled A, Kollet O, Ponomaryov T, et al. T e c emokine SDF-1 activates t e integrins LFA, VLA-4 andVLA-5 on immature uman CD34+ cells, role in transendot elial stromal migration and engraftment of NODSCID 1 Takai T. Calcium dependent activation of a multifunctional protein ki- mice. Blood, 2000, 95: 3289-3296. nase by membrane p osp olipids. J Biol C em, 1979, 254: 3692-3695. 6 , , . . : , 2 Gaugler MH, Squiban C, Mout onMA, et al. Irradiation en ances t e 2001. 193-212. support of aemopoietic cell transmigration, proliferation and differentia- ( : 2004-10-16) tion by endot elial cells. Br J Haematol, 2001, 113: 940-950. Rg3 张会来 王华庆 姚智 郝希山 Rg3 (PBSCT) PBSCT , 90 6 , 15 Rg3 IL-2 T ; ( ) B ; NK ; T B NK 9 mgkg+ IL-2 , NK , ,