G-蛋白偶联受体的糖基化中央到正常的生殖激素.docVIP

人类生殖更新1999年卷。 5, No.4 pp. 356–364 5，第4期第356-364 E European Society of Human Reproduction and Embryology 欧洲人类生殖及胚胎学会 Glycosylation of G-protein-coupled receptors for G-蛋白偶联受体的糖基化hormones central to normal reproducti中央到正常的生殖激素 functioning: its occurrence and role 功能：其发生和作用 Mark Wheatley 马克·惠特利 1 1 and Stuart R.Hawtin 斯图尔特R.Hawtin School of Biochemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK 学院生物化学，英国伯明翰大学，埃德巴斯顿2TT，英国伯明翰B15 Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a 许多激素，这是正常的生殖功能的中央调解，激活他们的生理效应 receptor which belongs to the large family of G-protein-coupled receptors (GPCR). 受体属于G-蛋白偶联受体（GPCR）的大家族。 Members of this family of receptor 这个受体家族成员 proteins are usually glycosylated on extracellular domains. 通常蛋白质糖化外域。 In recent years the role of this glycosylation in cell surface 近年来在细胞表面的这种糖基化作用 expression/protein folding, ligand recognition and receptor–effector coupling has been investigated. 表达/蛋白质折叠，配体识别和受体效应的耦合进行了研究。 This review 此意见 summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing 总结目前的知识受体的糖基化作用的促性腺激素释放的运作 hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), 激素（GnRH），促黄体激素/人绒毛膜促性腺激素（LH / hCG），卵泡刺激素（FSH）， oxytocin (OT) and vasopressin (AVP). 催产素（OT）和加压素（AVP）。 Key words: glycosylation/glycohormone receptors/gonadotrophin-releasing hormone receptor/oxytocin receptor/ 关键词：糖化/ glycohormone的受体/促性腺激素释放激素受体??/催产素受体??/ vasopressin receptor 加压素受体 TABLE OF CONTENTS 目录 Introduction 介绍 356 356 Glycosylation of receptors 糖基化的受体 356 356 Strategies for establishing that a receptor is glycosylated 建立糖化受体的策略 and for determining its functional significance 并确定其功能意义 357 357 Acknowledgements 致谢 363 363 References 参考文献 363 363 Introduction 介绍 The physiological actions of many hormones and 许多激素的生理作用和 neurotransmitters are mediated by rece