美藤果油辅助改善小鼠记忆的功效.pdf

202 2017, Vol.38, No.09 食品科学 ※营养卫生 美藤果油辅助改善小鼠记忆的功效 司 茹，郑梦思，邹莉波* （沈阳药科大学生命科学与生物制药学院，辽宁沈阳 110016 ） 摘  要：目的：通过小鼠实验探讨美藤果油改善记忆功能的作用。方法：72 只雄性SPF级昆明小鼠随机分为空 白组，模型组，美藤果油低、中、高剂量组（375.1 、750.2 、1 500.0 mg/ （kg ·d ），以体质量计，下同）及深海 / 鱼油组（1 500.0 mg kg ）。连续给药30 d后，进行避暗、跳台、Morris 水迷宫实验。结果：美藤果油750.2 、 1 500.0 mg/ （kg ·d ）剂量组能剂量依赖性地显著延长模型小鼠避暗和跳台实验的潜伏期，减少错误次数 P （＜0.05 ），而对Morris 水迷宫测试中的潜伏期及游泳路程百分比无显著影响。结论：美藤果油在375.1 ～ 1 500.0 mg/ （kg ·d ）的剂量范围内可能具有辅助改善小鼠记忆功能的作用。 关键词：美藤果油；改善记忆；避暗实验；跳台实验；Morris水迷宫 Effect of Sacha Inchi Oil on Improving Memory in Mice * SI Ru, ZHENG Mengsi, ZOU Libo (Life Science and Biopharmaceutics Academy, Shenyang Pharmaceutical University, Shenyang 110016, China) Abstract: Objective: To investigate the effect of sacha inchi oil on improving memory in mice. Methods: Totally 72 SPF male KM mice were randomly divided into control group, model group, sacha inchi oil low- medium-, high-dose groups / (375.1, 750.2 and 1 500.0 mg (kg·d)) and deep-sea fish oil group (1 500.0 mg/(kg·d)) . The animals were intragastrically administered for 30 days. After the experimental period, step-through test, step-down test and Morris water maze test were carried out. Results: In the medium- and high-dose groups, sacha inchi oil could prolong the latency time and reduce the number of errors in step-through test and step-down test (P 0.05), but had no significant effect on the latency time or the percentage of swimming distance in Morris water maze. Conclusion: Sacha inchi oil may play an imp