凉血消银汤联合复方黄连油膏治疗银屑病血热证的临床疗效和其对VEGF的影响.pdfVIP

提 要 目的：凉血消银汤联合复方黄连油膏治疗寻常型银屑病血热证的临床疗效观察及 其对 VEGF 水平的影响，探讨中药治疗银屑病的机理。 方法：将60例寻常型血热证银屑病患者随机分为两组，每组30例，即凉血消银 汤联合复方黄连油膏组和消银胶囊联合麻油组，连服2周为1疗程。4个疗程后判定 疗效。对两组患者治疗前后PASI评分、症状的改善情况及药物的安全性进行比较分 析，并采用ELISA法检测治疗前后血清VEGF水平的变化。 结果：通过临床观察发现，临床愈显率治疗组73.33%，对照组23.33%，总有效 率治疗组96.67%，对照组80.00%，治疗组与对照组比较有显著性差异(P＜0.05)，治 疗组优于对照组；两组组治疗前VEGF水平无明显差异（P＞0.05），治疗后VEGF水平 下降，治疗后两组组间比较差异有统计学意义（P＜0.01），治疗组优于对照组。 结论：凉血消银汤联合复方黄连油膏治疗寻常型银屑病血热证临床愈显率和总有 效率均高于对照组，其作用机理之一可能是降低银屑病患者血清中VEGF水平，从而 导致银屑病皮损中新生血管减少，达到治疗目的。 关键词 寻常型银屑病；凉血消银汤；复方黄连油膏；临床研究；VEGF ； Effect of Liang Xue Xiao Yin Decoction and Fu Fang Huang Lian Ointment in Treatment of Psoriasis Patients of Blood-Heat Syndrome Type and Its Impact on VEGF Equilibrium Specialty：Dermatology ，Surgery of TCM Tutor：Professor Song Yeqiang Author ：Li Jianna Abstract Objective： To explore the mechanism of Liang Xue Xiao Yin Decoction in treating psoriasis of blood-heat syndrome type by observing its clinical efficacy and impacton on serum level of Vascular Endothelial Growth Factor. Methods ： The 60 psoriasis vulgaris of blood-heat type patients are put into two groups at random. The treatment group is given Liang Xue Xiao Yin Decoction and Fu Fang Huang Lian Ointment (30 patients) ,the matched group is given Xiao Yin Jiao Nang and sesame oil (30 patients) respectively. The course of treatment is 8 weeks. Observe the PASI scores and improvement in symptoms and drug safety of the 2 groups before and after treatment ；Serum levels of VEGF was detected of 60 patients by ELISA before and after the treatment. Results ： Scores of PASI and syndrome all improved after treatment(P0.05).The clinical markedly effective rate and the total effective rate of treatment group are all better than the matched group and statistical c