通痹灵片药效对比实验.pdf

Modern Journ l of Integr ted Tr dition l Chinese nd Western Medicine 2004 J n, 13( 1) # 25 # 王丽新, 肖力强, 陈纪藩 ( 广州中医药大学第一附属医院, 广东 广州510405) [ ] 目的 验证经正交实验优 生产工艺后通痹灵片的药效方法 制作大鼠完全佐剂性关节炎模型, 用通 痹灵片与原通痹灵系列药( 通痹灵号片, 通痹灵 号片, 通痹灵冲剂) 及雷公藤多甙片, 进行药效对比实验结果 各治疗组 用药后均能减轻大鼠关节肿胀炎症, P 0. 0 1; 通痹灵系列药治疗后可使大鼠脾质量增加, P 0. 05; 而雷公藤多甙片 治疗后大鼠脾和胸腺质量不改变并略有减轻; 治疗后大鼠后肢关节病理切片检查显示: 通痹灵片治疗效果最佳, 使鼠 关节病变组织趋于正常结论 通痹灵片优 工艺改革较成功 [ ] 通痹灵片; 雷公藤多甙片; 关节炎; 脾质量; 胸腺质量 [ ] R965 [ ] A [ ] 1008- 8849( 2004) 0 1- 0025- 02 Comparative experiment of Tongbiling tablet curative effect WANG Lixin, X IAO Li qi ng, CHEN Jif n ( First Affili ted Hospit l of Gu ngzhou Universit y of T CM , Gu ngzhou 5 10405, Gu ngdong, Chin ) Abstract: Objective It is to verify the cur tive effect of the T ongbiling t blet optimized fter extr ct ion method. Meth ods Complete djuv nt rthrit is w s est blished in r t model. The effect of T ongbiling t blet, T ongbiling t blet, T ongbil ing t blet, T ongbiling gr nule nd multiglycosidove triptergii t blet on the models were comp red. Results The swelling of rthritis in r t in e ch group w s relieved fter dministr tion ( P 0. 0 1) . The m ss of t he r t! s spleen in ll T ongbiling groups incre sed ( P 0. 05) . But no ch nges or even some slightly decre sed in the m ss of the r t! s spleen nd thymus could be observed in multiglycosidove triptergii group. T he p thologic l observ tion on r t! s posterior limb joint fter tre t ment showed th t T ongbiling t blet h d t he best effect in improving the lesion of joint. Conclusion The cur tive effect of T ongbiling t blet h d been optimized fter extr ction met hod. Key words: T ongbiling t blet; multiglycosidove triptergii; rt hritis; m ss of spleen; m ss of t hymus ( RA)