复方黄柏液联合茵陈蒿汤加减治疗痤疮临床观察和机理初探.pdfVIP

提 要 目的：观察复方黄柏液联合茵陈蒿汤加减治疗痤疮脾胃湿热证的临床疗效，并探 讨其治疗痤疮脾胃湿热证的作用机理。方法：临床研究：将 60 例痤疮患者随机分成 治疗组（复方黄柏液＋茵陈蒿汤加减）、对照组（玫芦消痤膏＋茵陈蒿汤加减），1 周 为 1 个疗程，每周复诊一次，共观察 8 个疗程。观察两组患者治疗前后皮疹类型、皮 疹数量、痒痛程度等积分的变化。实验研究：采用平皿法对金黄色葡萄球菌进行培养 并观察复方黄柏液的抑菌效果。结果：临床研究显示：治疗组愈显率为 93.33 ％，总 有效率为 96.67 ％，对照组愈显率为 70.00 ％，总有效率为 80.00 ％，两组比较差异有 显著性（P ＜0.05 ）。实验研究显示：复方黄柏液有抑制金黄色葡萄球菌的作用。结论： 复方黄柏液联合茵陈蒿汤加减治疗痤疮脾胃湿热证疗效确切，复发率低，其作用机理 可能与抗炎、抗病原微生物、调节免疫等有关。 关键词 痤疮；临床研究；实验研究；复方黄柏液 The Clinical and Experimental Study on Treating Acne Vulgaris by Compound Phellodendron Liquid combined with The Yinchenhao Decoction Modified Speciality:Dermatology,Surgery of TCM Author:Xu Jinru Tutor:Professor Song Yeqiang Abstract Objective:To observe clinical efficacy for treating acne of Damp-Heat Type in spleen and stomach by Compound Phellodendron Liquid （CPL ） combined with The Yinchenhao Decoction Modified;explore the therapy mechanism of CPL in acne of Damp-Heat Type. Method:60 patients were separated at random into group with CPL combined with Yinchenhao Decoction Modified and group with MeiLuXiaoCuoGao combined with Yinchenhao Decoction Modified. During 8 weeks’treatments, the changes of degree of prurit and pain, papula and pustule were observed.In the experimental study,staphylococcus epidermidis were cultured by microplating method and the bacteriostatic action of CPL against staphyloccocus aureus rosenbach was constructed in vitro.Result:Compared with group with MeiLuXiaoCuoGao, cure and obvious effect rate is 93.33% with total effect rate of 96.67% and there are notable difference between two groups （P ＜0.05 ）.The experiment shows that CPL can inhibit the growth of staphyloccocus aureus rosenbach in vitro. Conclusion: