原创力文档Antinuclear Antibodies and Patterns of Nuclear Immunofluorescence in Type 1 Autoimmune Hepatitis：（抗核抗体和核免疫荧光模式1型自身免疫性肝炎）.pdfVIP
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Digestive Diseases and Sciences, Vol. 42, No. 8 (August 1997), pp. 1688 ± 1696
Antinucle ar Antibodie s and Patterns of
Nucle ar Immuno¯ uorescence in Type 1
Autoimmune Hepatitis
ALBE RT J. CZAJA, MD, FABIO CASSANI, MD, MICHELA CATALETA, MD,
PAO LO V ALENTINI, MD, and FRANCE SCO B . BIANCHI, MD
To de te rmine the signi® cance of antinucle ar antibodie s and the ir patte rns of indire ct
immuno¯ uore scence in type 1 autoimm une he patitis, sera from 99 patie nts we re e valuate d.
Patie nts with antinucle ar antibodie s had a lowe r fre que ncy of live r transplantation (6% vs
22% , P 5 0.04) than serone gative patie nts. They we re also more commonly HLA-DR4-
positive than serone gative patie nts ( 56% vs 30% , P 5 0.05) and normal subje cts ( 56% vs 30% ,
P 5 0.004) . The 42 patie nts with antinucle ar antibodie s and a diffuse patte rn of indire ct
immuno¯ uore scence had highe r serum tite rs of ANA (serum tite rs $ 1:500, 71% vs 14% , P ,
0.0001) and SMA (serum tite rs $ 1:500, 69% vs 27% , P 5 0.003) than the 22 patie nts with
antinucle ar antibodie s and a speckle d patte rn. The se patie nts, howe ve r, we re othe rwise not
distinguishe d by clinical fe ature s and tre atment re sponse . Patie nts with a speckle d patte rn
had A1-B 8-DR3 m ore fre que ntly than patie nts with a diffuse patte rn (65% vs 23% , P 5
0.005) and normal subje cts (65% vs 13% , P ,
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