原创力文档Apoptosis induced in L1210 leukaemia cells by an inhibitor of the chymotrypsin-like activity of the proteasome：（L1210白血病细胞凋亡诱导的蛋白酶体抑制剂chymotrypsin-like活动）.pdfVIP
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Apoptosis 1997; 2: 455–462
Apoptosis induced in L1210 leukaemia cells
by an inhibitor of the chymotrypsin-like activity
of the proteasome Apoptosis . Vol 2 . No 5 . 1997
C. Wójcik, T. Stoklosa, A. Giermasz, J. Golab,
R. Zagozdzon, J. Kawiak, S. Wilk, A. Komar, A. Kaca,
J. Malejczyk and M. Jakóbisiak
Laboratory for Molecular Cell Biology, Department of Histology and Embryology,
Institute of Biostructure, Warsaw, Medical School, Warsaw, Poland (C. Wójcik,
A. Komar, J. Malejczyk); Department of Immunology, Institute of Biostructure,
Warsaw Medical School (T. Stoklosa, A. Giermasz, J. Golab, R. Zagozdzon, A. Kaca,
M. Jakóbisiak); Department of Pharmacology, Mount Sinai School of Medicine, City
University of New York, New York, USA (C. Wójcik, S. Wilk); Department of Clinical
Cytology, Postgraduate Center of Medical Study, Warsaw, Poland (J. Kawiak)
Of a number of factors involved in apoptosis, protease biological factors, leading to activation of different
activity may play a crucial role. We show that N-ben- signal transduction pathways. However, all these
zyloxycarbonyl-Ile-Glu(O-t-butyl)-Ala-leucinal (PSI), a signals converge in a common executioning system,
selective inhibitor of the chymotrypsin-like activity of
the proteasome, induces massive apoptosis in murine which, most probably, involves the members of the
leukaemia L1210 cells. At 50 nM concentration, PSI interleukin-1β converting enzyme (ICE)/Ced3 fam-
induces a block of cytokinesis, while higher concentra- ily of cysteine proteases (caspases).1,2,3
tions (500 nM) cause S phase block and massive apop- The ubiquitin-proteasome proteolytic pathway is
tosis. Z-Leu-leucinal, a specific calpain inhibitor, did not
induce apoptosis. In contrast to previous re
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