老年下肢动脉硬化症患者氧化低密度省略皮功能的关系及普罗布考的干预研究范利.pdfVIP

200567 3 　ChinJ Geriatr Heart BrainVessel Dis,Jun2005, Vol 7, No.3 ·151 · ·· 范利, 朱冰坡, 李小鹰, 曹剑, 刘涛 (, 100853) :目的　评价老年下肢动脉硬化症(LEASD)患者血清氧化低密度 蛋白(ox-LDL)水平与内皮舒张功能的关系, 同时评估普罗布考对ox-LDL 水平与内皮舒张功能的影响。 方法　采用随机、开放、自身对照和组间对照, 将 54 例 老年LEASD 患者分为两组, 其中1 组为普罗布考组(33 例)服用普罗布考0.5 g, 2 次 d, 同时服用常规抗血小板药物 (阿司匹林 100 mg, 1次 d);对照组(21例)仅服用阿司匹林(100 mg, 1次 d), 疗程均为12 周。 分别于服药前后检测 血清ox-LDL水平, 同时采用高分辨率超声技术, 对治疗前后血管内皮舒张功能进行检测。 结果　治疗前, 所有患者 内皮依赖舒张功能(FMD)与其ox-LDL 水平未呈现出线性关系;治疗后, 普罗布考组FMD 明显增加, 血清ox-LDL 水 平显著降低;治疗后血清ox-LDL 水平与FMD 呈现出线性关系。 结论　普罗布考能够改善老年LEASD 患者内皮功 能, 并能显著降低血清ox-LDL 水平;普罗布考组患者内皮功能改善与其ox-LDL 水平的降低有关。 :动脉硬化, 闭塞性;腿; 蛋白类, LDL;内皮;普罗布可;血管舒张 :R543.5　　　　　　:A　　　　　　:1009-0126(2005)03-0151-03 Relationship between plasma ox-LDL level and endothelial function of the lower-extremity atherosclerotic disease in the elderly and an intervention study with probucol FAN Li, ZHU Bing-po, LI iao-ying, et a l (Chinese PLA General Hosp ita l, Beij ing 100853, China ) Abstract:Objective 　To evaluate the relationship between plasmaox-LDLlevel and endothelial relaxing func- tion of the lower-extremity atherosclerotic disease (LEASD)in the elderly and the effect of probucol on the plasma ox-LDL level and endothelial relaxing function.Methods　Fifty-four patients with LEASD were ran- domly divided into treatment group, including 33 subjects who received probucol 0.5g, bid with regular an- tithrombotic therapeutics (aspirin 100mg, qd), and controlgroup, including 21subjectswho received only as- pirin 100 mg, qd.The total period of treatment was 12 weeks.The plasma ox-LDL levels before and after treatmentweremeasured.Theflow-mediated (endotheliu