消银1号方治疗寻常型银屑病临床疗效观察和对动物模型的研究.pdfVIP

提 要 目的：观察消银1号方治疗银屑病血热内蕴证的疗效，探讨消银1号方治疗银屑 病的作用机理。 方法：临床研究：将60例寻常型银屑病患者随机分成2组，治疗组（消银1号方） 和对照组（百癣夏塔热片），2周为一疗程，共观察4疗程，实验研究：通过建立小鼠实 验模型，模拟银屑病角化不全和表皮过度增生。观察治疗组、对照组对小鼠阴道上皮有 丝分裂及尾部鳞片颗粒层影响。 结果：消银1号方治疗银屑病血热内蕴证的临床疗效明显优于百癣夏塔热片，且 不良反应发生率低。同时消银1号方具有明显抑制小鼠阴道上皮细胞有丝分裂，促进 鼠尾鳞片颗粒层形成的作用。 结论：消银1号方治疗寻常型银屑病疗效确切，复发率低，作用机理可能与抑制 表皮细胞分裂、促进颗粒层的形成、调节免疫、抗炎等有关。 关键词 消银1号方；银屑病；临床观察；实验研究；机理探讨 The clinical study of Qingrehuayutang treating psoriasis of blood-heat and blood stasis type and its influence on mice ’s vaginal epithelial cells and empennage squamous epithelial cell. Specialty：Dermatology,Surgery of TCM Tutor ：Professor Song yeqiang Author ：Lian Qing Abstract Objective: to observe the xiao yin 1 hao fang away heat treatment of psoriasis imbedded blood type and effect on mice vaginal epithelial cells and tail squamous epithelial cells, and discuss the influence away xiao yin 1 hao fang decoction in the treatment of psoriasis blood hot intrinsic mechanism type. Methods: clinical research: 60 patients with psoriasis patients were randomly divided into ordinary type 2 groups, Chinese traditional medicine group (xiao yin 1 hao fang group) and the control group ((bai xuan xia ta re pian group), 8 weeks, to observe the treatment lesions and the number, location, and type of itch to determine the symptom such as degree change effects. Experimental research: to establish simulation model, mice, psoriasis skin excessive proliferation and Angle change insufficiency. Observation of traditional Chinese medicine group, western medicine control mice vaginal epithelial mitosis and rat tail scales granular layer effects, and the establishment of saline control group. Results: clinical research: Chinese medicine group, the total effe