消瘿方对桥本氏甲状腺炎血清过氧化物酶抗体(TPO-Ab)浓度的干预性探究.pdfVIP

提 要 目的：观察消瘿方对桥本氏甲状腺炎患者血清过氧化物酶抗体（TPO-Ab ）浓度 的影响。方法:将临床诊断为桥本氏甲状腺炎的60例患者随机分为两组，其中，对照 组30例，予以火把花根片治疗；治疗组30例，予以消瘿方治疗；两组均以8周为一个 疗程，观察一个疗程。结果:经临床观察，两组在降低血清过氧化物酶抗体浓度 （TPO-Ab ）的水平上均有疗效，且疗效无明显差异。在改善临床症状体征上治疗组 明显优于对照组（P0.05）。结论:消瘿方明显降低桥本氏甲状腺炎患者血清过氧化物 酶抗体（TPO-A b ）浓度水平，在改善临床症状上具有显著优势，且能够减少因药物 所致副作用的产生机率。显示了以清热解毒、活血散结治疗桥本氏甲状腺炎的可行性， 提示中医药辨证治疗在桥本氏甲状腺炎减轻疾病的发展，扼制其进一步发展成甲减具 有明显优势。 关键词 血清过氧化物酶抗体；消瘿方；火把花根片；干预性研究 Clinical Observation of The Effect of XiaoYingFang on thyroid peroxidase Antibody in Patients With hashimoto’s thyroiditis Speciality: Internal Medicine Of TCM Author: LuanYingni Tutor: Professor ZhaoQuanlin Abstract Objective: To observe the effect on thyroid peroxidase Antibody (TPO-Ab) XiaoYingFang in patients with hashimoto’s thyroiditis(HT)Methods: 60 patients diagnosed HT were randomly classified into two groups with the drugs of normal thyroxine . There were 30 patients treated with HuoBaHuaGenPian in control group, others were treated with XiaoYingFang in treated group.Eight weeks were a course of treatment. Results: Both the two group had the healing efficacy on lowering the TPO-Ab ,and the effect were similar.The effect of the treated group was obviously better than the control group in improving clinical symptoms, The difference was significant compared to the control group(P0.05) Conclusions:XiaoYingFang could lower the TPO-Ab of HT patients,it had remarkable superiority in improving clinical symptoms ，and it could reduce the side-effect. This research testifies the advantages of the HT ’s treatment with the method of QingReJieDuHuoXueSanJie It also confirmed that traditional Chinese medicine had considerable clinical value and widest