消克康胶囊干预40岁以上2型糖尿病和合并高脂血症的临床研究.pdfVIP

提 要 目的：观察消克康胶囊对40岁以上人群2型糖尿病及合并高脂血症患者的临床疗 效，及对胰岛素抵抗（IR）、肿瘤坏死因子（TNF-α）等的作用，探讨作用机制。方 法：将纳入病例随机双盲法分为两组，排除脱落及资料不全等患者后，治疗组45例， 对照组41例, 保持原饮食、运动及口服西药治疗，分别给予消克康胶囊与安慰剂，观 察患者的临床症状疗效及治疗前后空腹血糖（FPG）、餐后2h血糖（2hPG）、糖化血 清蛋白 （GSP）、空腹胰岛素 （FINS）、稳态模型法计算胰岛素抵抗指数 （Homa-IR=FINS ×FPG/22.5）、血脂[总胆固醇 （TC）、甘油三酯 （TG）、高密度脂蛋白胆固醇 （HDL-C）、 低密度脂蛋白胆固醇（LDL-C）]、谷丙转氨酶（ALT）等血液安全指标及TNF-α水平 的变化。结果：消克康组显著改善患者症状，显著降低FPG、2hPG、GSP、TC、LDL-C、 ALT水平，并有降低血清TNF-α、Homa-IR的作用（P＜0.01～0.05），与对照组比较 有统计学意义。结论：原有治疗基础上加服消克康胶囊治疗40岁以上人群2型糖尿病 及合并高脂血症疗效可靠，具有降糖、调脂、抗炎、改善IR等作用，值得推广使用。 关键词 消克康胶囊；40岁以上人群；2型糖尿病； 高脂血症； 胰岛素抵抗； 肿瘤坏死因子 Clinical Study on Treatment of type 2 diabetes and complicating hyperlipemia of people over the age of 40 with Xiaokekang capsule Speciality ：cardiovascular disease, clinical medicine of integrated TCM and western medicine. Author ：ZHANG Ling Tutor：Prof. ZHANG Wengao Abstract Objective: TO observe the therapeutic effect of Xiaokekang capsule on type 2 diabetes and complicating hyperlipemia of people over the age of 40,and also to observe the expression of serum TNF- α level and Insulin Resistance (IR)of them. Method: selected cases were randomly double-blind divided into 2 groups, after the off cases and the incomplete information cases were excluded: one group(n=41) were treated with routine treatment and placebo, the test group(n=45) treated by toutine treatment and Xiaokekang capsule. We observed therapeutic effect of clinical symptoms, the changes of FBG,2hPG,GSP, FINS, Homa-IR was calculated by Homa-IR=FINS ×FPG/ 22.5,blood lipids (TC,TG,HDL-C,LDL-C),ALT and other plasma indexes,serum TNF- α level of all the patients. Result: Xiaokekang capsule could