活血补肾方治疗激素性股骨头坏死的临床及相关实验研究.pdfVIP

提 要 目的：研究活血补肾方对激素性股骨头坏死的临床疗效，并探讨其可能作用机制。 方法：临床观察将45 例激素性股骨头坏死患者，随机分为治疗组 24 例、对照组 21 例，治疗组服用活血补肾方，对照组服用仙灵骨葆胶囊，比较两组治疗前后各临 床症状积分及实验室检查变化的差异。实验研究将 24 只新西兰大白兔随机分为正常 组、模型组、对照组、治疗组等四组，治疗组给予活血补肾方，对照组给予仙灵骨葆 胶囊。给药8周后进行血清骨钙素（BGP）、血流变指标的测定。 结果：临床观察显示，治疗组与对照组总体优良率比较，差异有显著性；组间实 验室检查结果及症状改善方面差异有显著性。动物实验显示模型组血清 BGP 明显降 低，血液粘度增高；对照组与治疗组各项指标有明显改善。治疗组以上各项指标与对 照组比较，皆有显著性差异。 结论：通过临床疗效观察及动物实验研究，活血补肾方无明显毒副作用，疗效优 于对照组。其作用机制可能与改善血液流变学、改善微循环、降低骨内压有关，拮抗 脂代谢紊乱，调节钙磷代谢、促进骨质形成有关。 关键词 活血补肾方；激素性股骨头坏死；临床观察；动物实验 Clinical and Experimental Study on the Therapy of Steroid-induced Avascular Necrosis of the Femoral Head by HuoXueBuShen Fang Speciality：Orthopaedicics of TCM Author ：Guo Ya Tutor：Professor Zhang Shihua Abstract Objective ：To study the curative effect of HuoXueBuSen Fang in treating steroid-induced avascular necrosis of the femoral head （SANFH）and to investigate its possible mechanism ． Methods ：In the clinical study，HuoXueBuShen Fang was used in 24 cases of SANFH as the treated group compared with 21 cases treated by XianLingGuBao Capsule for curative effect observation ．The difference on cure rate，clinical symptoms，laboratory examinations between the two groups were observed ．In the experimental study，24 New Zealand rabbits were randomly divided into 4 groups ：normal group ，model group ，control group and treated group ．The rabbits in control group were treated with XianLingGuBao Capsule and HuoXueBuShen Fang was used in treated group ．8 weeks later，to determine the content of Bone gla protein (BGP) 、Hemorheology ． Results ：In the clinical study ，there was quite difference in comparison with pretreatment and post-treatment in treated groupe and contrastive groupe and the ef