活血消癓方及化瘀止痛方对子宫腺肌病痛经免疫调节作用的影响研究.pdfVIP

提 要 目的：观察活血消癥方与化瘀止痛方分期治疗子宫腺肌病痛经的临床疗效，并通 过观察活血消癥方与化瘀止痛方分期治疗子宫腺肌病痛经对血液相关免疫指标的影 响，探讨活血消癥方与化瘀止痛方对子宫腺肌病痛经免疫调节作用的影响。方法：共 观察子宫腺肌病痛经患者50例，治疗组26例，分期服用活血消癥方与化瘀止痛方； 对照组 24 例，分期服用丹黄祛瘀胶囊和散结镇痛胶囊，观察两组患者疗效及对子宫 体积大小、血清CA125、血清EMAb、全血T细胞亚群、血清补体（C3、C4）的影响。 结果：两组患者治疗后痛经症状明显改善，疗效比较有显著性差异（P0.05 或 P0.01）；治疗组患者疗后子宫体积明显缩小，与疗前比较有显著性差异（P0.01）， 对照组疗后较疗前比较无显著性差异（P0.05），组间比较有显著性差异（P0.05）； 两组患者疗后血清EMAb阳性率降低（P0.05），但组间比较无显著性差异（P0.05）； 两组患者疗后血清CA125值均明显降低 （ P0.05），组间比较有显著性差异 （P0.05）； 治疗组疗后 CD4 值较疗前明显升高，CD8 明显降低，CD4/CD8 比值明显升高，有显著 性差异（P0.01）；治疗后组间比较，CD4、CD8、CD4/CD8 有显著性差异（P0.05 或 P0.01）；两组患者疗后血清补体 C3、C4 值均升高，组间比较血清补体 C3 有显 著性差异（P0.05），血清补体 C4 无显著性差异（P0.05）。结论：活血消癥方与化 瘀止痛方分期治疗子宫腺肌病痛经疗效较好，可明显改善患者机体的免疫失衡状态。 关键词 活血消癥方；化瘀止痛方；子宫腺肌病痛经；免疫调节作用 The Research on the Immunomodulatory Effects of HuoXueXiaoZheng Fang and HuaYu ZhiTong Fang to Adenomyosis with Symptoms of Dysmenorrhea Speciality: Gynecology of TCM,The study of menstruation sickness and sterility Tutor: Professor Ye Qing Author: Zhang Chunyan Abstract Objective: This study was performed to observe the clinical effectiveness of the treatments on patients suffering from dysmenorrhea with ademyosis by stages using HuoXueXiaoZhengFang (HXXZF) and HuaYuZhiTongFang (HYZTF). Their effects on blood-related immune parameters are observed, which is to explore their immunomodulatory effects in patients suffering from dysmenorrhea with ademyosis. Methods: Fifty adenomyosis patients suffering from dysmenorrhea (twenty-six for the treatment group and twenty-four for the control group) were enrolled. The treatment group took HXXZF and HYZTF at stage, while the control group took DanHuangQuYu capsule and S