消癥汤对子宫内膜异位症免疫功能影响的探究.pdfVIP

提 要 目的：观察以活血祛瘀、化痰消癥立法的消癥汤治疗子宫内膜异位症的临床疗效， 并通过观察消癥汤对血液中相关免疫指标的影响，探讨消癥汤对子宫内膜异位症患者 免疫功能的调节机理。方法：将 60 例痰瘀互凝型子宫内膜异位症患者，按随机区组 法随机分为两组，治疗组 30 例，用消癥汤治疗；对照组 30 例，用散结镇痛胶囊治疗。 观察两组患者治疗前后临床症状、体征的改善情况，并分别测定两组患者血清抗子宫 内膜抗体(EmAb)、外周血自然杀伤细胞(NK 细胞)活性、T 细胞亚群分类（CD 、CD 、 3 4 CD 、CD /CD ）及癌抗原－125 (CA )等指标的变化情况。结果：消癥汤治疗子宫 8 4 8 125 内膜异位症的愈显率为60.00%，总有效率为 90.00%，其临床疗效及中医证侯疗效明 显优于对照组。实验室检测结果表明：子宫内膜异位症患者存在免疫功能紊乱，治疗 前患者血清 CA 水平、EmAb 阳性率明显升高，CD 、CD 、CD /CD 均较正常值 125 3 4 4 8 降低，外周血NK 细胞活性明显下降；治疗后两组患者血清 CA125 水平、EmAb 阳性 率显著降低，CD 、CD 、CD /CD 比值均明显升高，NK 细胞活性均上升。结论：消 3 4 4 8 癥汤可有效改善患者的临床症状和体征，对子宫内膜异位症有较好的临床疗效；并可 改善患者免疫功能，维持机体免疫功能的稳定。 关键词 子宫内膜异位症；消癥汤；临床疗效；免疫功能 Immunity Function Study on the Effect of XiaoZheng Decoction to Endometriosis Speciality:Gynecology of TCM, The Study of Endometriosis Author : Zhao Chunxiang Tutor :Professor Liu Jinxing Abstract Objective: To observe the curative effect and the effect on the immunity indexes of XiaoZheng Decoction in treating Endometriosis. To explore the mechanism of rectifying the immunity.Methods:60 patients were divided into the treatment group(30 cases,treated with XZD) and the control group(30 cases,treated with SanJieZhenTong Capsule) at random. Before and after treatment, the clinical symptoms, physical sign and the immunity indexes, such as Cancer Antigen 125 (CA ), Endometrium Antibody (EmAb) , T cell such as 125 subgroups(CD , CD , CD , CD /CD ) and the activity of blood NK cell were observed. 3