消癥汤治疗痰瘀互结型子宫内膜异位症的临床探究.pdfVIP

提 要 目的：探讨以活血祛瘀、化痰消癥立法的消癥汤治疗子宫内膜异位症的疗效及 作用机理。方法：将 60 例痰瘀互结型子宫内膜异位症患者随机分为两组，治疗组 30 例，用消癥汤治疗；对照组 30 例，用散结镇痛胶囊治疗。观察两组患者治疗前后临 床症状、体征的改善情况，并分别测定两组患者血液流变学（高切全血粘度、低切 全血粘度、血浆粘度、红细胞压积、血沉、红细胞聚集指数、纤维蛋白原）、血清抗 子宫内膜抗体(EmAb)、癌抗原－125 (CA125)等指标的变化情况。结果：消癥汤治疗 本病临床疗效总有效率为 93.33%，愈显率为 73.33%，临床症状体征显著改善，明 显优于对照组；实验室检测结果表明：治疗前子宫内膜异位症患者存在血液流变学异 常，血清 CA125 水平、EmAb 阳性率明显升高，治疗后显示本方能明显改善血液流变 性、显著降低血清 CA125 水平和 EmAb 阳性率。结论：消癥汤对痰瘀互结型子宫内 膜异位症具有较好的疗效，改善血液流变性、调整机体免疫功能可能是其部分作用机 理。 关键词 子宫内膜异位症；祛瘀化痰法；血液流变学；EmAb ；CA125 Clinical Study on the Curative Effect of XiaoZheng Decoction in Treating Endometriosis Specialty: Gynecology of TCM, The Study of Endometriosis Author : Liu Xiaojie Tutor: Professor Liu Jinxing Abstract Objective: To observe the curative effect of XiaoZheng Decoction (ZHD) in treating endometriosis and to explore its mechanism. Methods: 60 patients suffering from endometriosis with the characteristic of intermingled phlegm and blood stasis were divided into the treatment group (30 cases, treated with XZD) and the control group (30 cases, treated with SanJieZhenTong Capsule) at random. Before and after treatment, the clinical symptoms and the improvement in physical signs were observed; Changes of such indexes as blood rheology (High-shear Whole Blood Viscosity, Low-shear Whole Blood Viscosity, Plasma Adherence, Hematokrit, Blood Sedimentation, Aggregative Index of RBC, Fibrinogen), antiendometrial antibody (EmAb), CA125 were measured. Results: The general effective rate of XiaoZheng Decoction in treating endometriosis was 93.33 percent, and the