清热利湿饮治疗血热型银屑病和与SP、β-EP的相关性研究.pdfVIP

提 要 目的：观察导师应用清热利湿饮治疗血热型银屑病的临床疗效，并通过研究银屑 病患者心理健康水平及对患者治疗前后 P 物质（SP）、β-内啡肽（β-EP ）含量检测， 观察清热利湿饮对神经肽的影响，探讨精神因素在银屑病发病中的重要作用。方法： 将 60 例血热型银屑病患者随机分成两组，各 30 例，I 治疗组予以清热利湿饮，II 对照组予以清热凉血饮，疗程12周，观察皮损分布范围、红斑严重程度、鳞屑多少、 浸润程度及瘙痒程度等。采用 ZUNG 自我评定抑郁量表（SDS）、ZUNG 自我焦虑量 表（SAS ）调查30例银屑病患者发病前精神状态。治疗组取20例进行治疗前后 SP、 β-EP 含量检测，并与 20 例健康成年人作对照。观察治疗组治疗前后 SP、β-EP 含量 的变化。 结果：治疗组治愈率56.67％，总有效率93.33％；对照组治愈率30.00％， 总有效率70.00％。两组相比有差异性（P＜0.05），治疗组疗效优于对照组。银屑病 患者总体倾向有轻、中、重度的抑郁和焦虑，抑郁和焦虑的患者分别占总数的66.67 ％和 76.67％。治疗后 SP、β-EP 含量较疗前显著降低，疗前疗后比较差异有显著性 （P＜0.01）。 结论：清热利湿饮治疗血热型银屑病疗效确切，其作用机理可能是与 调节精神因素、抗病原微生物、抑制表皮细胞增殖、抗炎、调节免疫、调节代谢障碍 等有关；心理因素在银屑病的发生中起了重要作用。 关键词 血热型银屑病；精神因素；临床研究；中医治法；作用机理 Clinical Study on psoriasis of blood heat type and the relativity of the content of SP and β-EP with the Drink of Clearing Heat and Removing Damp Specialty：Dermatology, Surgery of TCM Author ：Wang Lei Tutor：Professor Du Xixian Abstract Objective:To observe clinical efficacy of psoriasis of blood heat type patients treated with the Drink of Clearing Heat and Removing Damp by tutor. To observe the impact on neuropeptide by the Drink of Clearing Heat and Removing Damp through studying the mental and healthy level of psoriasis of blood heat type patients and the content of SP and β-endorphin before and after treatment .To explore the effect on the occur of psoriasis by psychic factor. Method: 60 psoriasis of blood heat type patients were divided into two groups at random with the ratio of 1:1. Treatment group with the Drink of Clearing Heat and Removing Damp ,matched group with the drink of Clearing Heat and Cool The Blood. During 12 weeks’ treatments,damage and distribution of skin, severity of erythema , quantity of dry scaly skin bits,degree of p