清化调胃饮治疗幽门螺杆菌相关浅表性胃炎（湿热中阻型）临床探究.pdfVIP

提 要 目的：观察清化调胃饮治疗幽门螺杆菌相关浅表性胃炎（HpASG）,中医辨证为湿 热中阻型的临床疗效，并从理论和临床研究两个方面探讨清化调胃饮治疗湿热中阻型 HpASG的机制。 方法：临床选择符合纳入标准的 HpASG 患者 60 例，随机分为两组，两组患者在 年龄、性别、病程、病情严重程度等方面无明显差异，具有可比性(P﹥0.05)。治疗 组（30 例）给予清化调胃饮，对照组（30 例）给予奥美拉唑、甲硝唑、阿莫西林， 连用1周后停用甲硝唑和阿莫西林，继用奥美拉唑。两组均以4周为一疗程。用药结 束后进行临床症状、胃镜下粘膜相、Hp根除率等疗效性观察及血、尿、粪常规，心、 肝、肾功能等安全性检测。 结果：药物治疗后两组患者在临床症状控制率 （痊愈率+显效率）方面，治疗组 优于对照组（P ﹤0.05）；在总有效率方面，两组无显著性差异（P﹥0.05）；在中医症 状总积分的改善方面，治疗组明显优于对照组（P ﹤0.01）；在胃镜下粘膜改善及 Hp 根除方面，两组无显著性差异（P﹥0.05）。治疗组疗程结束时血、尿、大便常规及心、 肝、肾功能等检测无明显变化。 结论：清化调胃饮治疗幽门螺杆菌相关浅表性胃炎湿热中阻证安全、有效，值得 进一步研究推广。 关键词 清化调胃饮；幽门螺杆菌相关浅表性胃炎；湿热中阻；临床研究 Clinical Study of Qing-hua-tiao-wei-yin on Helicobacter Pylori-associated superficial gastritis to Treat Shire Zhongzu Syndrome Specialty：Gastroenterology.Internal Medicine of TCM. Author ：Zhang Yanbin Tutor： Professor Lu Guangchao Abstract Objective: To observe the effect of Qing-hua-tiao-wei-yin (QHTWY) on Helicobacter Pylori-associated superficial gastritis (HpASG) and explore the mechanism of it. Methods: 60 patients with HpASG were divided into two groups at random: the treatment group and the control group.The treatment group was given QHTWY, and the control group was given omeprazole, metronidazole, amoxicillin ．4 weeks were set as a course of treatment.The clinical effects of each group were observed during the course. Results: The treatment group in clinical symptom control rate (recovery rate + significant efficiency) is better than that of the control group (P0.05), the total effective rate in two groups non-significance difference (p0.05). In the improvement of TCM symptoms total score, the treatment group was better than control group (p0.01). In the endoscopic observati