青蒿素类衍生物抗炎免疫抑制活性研究进展王峻霞.pdfVIP

# 336# International Journal of Pharm aceuticalR esearch 2007 Oct; 34( 5) 1 1 1, 2* , , ( 1. , 201203; 2. , 201203) : 青蒿素类衍生物具有抗炎和免疫抑制活性临床研究结果表明, 青蒿素类衍生物对各类红 斑狼 皮炎及关节炎有效;研究表明, 青蒿素类衍生物在多种疾病动物模型上具有抗炎和免疫抑 制活性为了研究和获得免疫抑制活性更高的化合物, 一系列经过结构改造后合成的新型青蒿素 类化合物相继被报道但到目前为止, 有关青蒿素类衍生物免疫抑制活性的作用机制尚不清楚 本文主要综述了近年来青蒿素类衍生物抗炎和免疫抑制药理作用及其作用机制的研究进展 : 青蒿素; 青蒿素类衍生物; 抗炎; 免疫抑制 : R392; R593; R979. 5 : A : 1674-0440( 2007) 05-0336-05 The ant-i inflamm atory and imm unosuppressive activity of artem isinin derivatives 1 1 1, 2 WANG Jun-xia , TANGW ei, Z O Jian-ping ( 1. Laboratory of Immunopharmacology, S tateK ey Laboratory of D rug R esearch, Shanghai Institute of MateriaM ed ica, Ch ineseA cademy of Sciences, Shanghai, 201203, China; 2. Laboratory of Imm unology and irology, Shanghai University of Traditional Ch ineseM ed icine, Shanghai, 201203, Ch ina) Abstract: Artem isinin and its derivatives exhibitpotent ant-i inflammatory and mi munosuppressive activ-i ty. In clinical investigations, theywere used for the treatment of system ic lupus erythem atosus ( SLE), dermatitis and rheumatic arthritis (RA) w ith prom ising results. In laboratory studies, they showed ant-i inflammatory and mi munosuppressive effect on various anmi aldiseasemodels. Recently, a series of new artem isinin derivatives have been synthesized to develop potent mi munosuppressive agents. However, the underlying mechanisms mediating their ant-i inflammatory and mi munosuppressive effects are still un- known. Here,