盆腔炎颗粒治疗慢性盆腔炎疗效观察和对模型大鼠炎症因子IL-6、IL-4影响的研究.pdfVIP

提 要 目的：观察盆腔炎颗粒治疗血瘀肾虚型慢性盆腔炎的临床疗效及对大鼠炎症细胞 因子的影响，探讨其作用机理。 方法：临床选择符合病例选择标准者 71 例，其中治疗组 35 例，对照组 36 例。 治疗组口服盆腔炎颗粒，对照组盆炎净颗粒，观察两组的临床疗效。将制备的慢性盆 腔炎大鼠模型 60 只，随机分为7 组，药物干预后，测定大鼠血清的炎症细胞因子（IL-6、 IL-4 ）的浓度。 结果：临床研究显示，治疗组总有效率 85.71%，显著优于对照组（P0.05 ）。 治疗后两组患者的综合积分、中医症状积分、局部体征积分比较均有统计学差异 （P0.05 ），治疗组明显优于对照组。动物实验研究显示，慢性盆腔炎模型大鼠血清 前炎症细胞因子 IL-6 水平较正常组大鼠升高，抗炎症细胞因子 IL-4 水平较正常组大 鼠降低。药物干预后，各治疗组大鼠较模型组大鼠血清前炎症细胞因子水平下降，抗 炎症细胞因子水平升高（P0.05 ）。 结论：盆腔炎颗粒治疗血瘀肾虚型慢性盆腔炎有较好的临床疗效，通过动物实验 揭示其作用机理可能是调节炎症细胞因子水平从而缓解或消除慢性炎症反应。 关键词 盆腔炎颗粒；慢性盆腔炎；疗效观察；IL-6 ；IL-4 The Clinical Study of PenQiangYan Granule on Treating Chronic Pelvic Inflammatory Disease and The Effect on inflammatory cytokines IL-6 and IL-4 of the Experimental Model Rats Speciality: Gynecology of TCM Author:Li Ying-xiao Tutor: Prof. Liu Rui-fen Abstract Objective ：Exploring the clinical efficacy of Pen Qiangyan Granule on treating chronic pelvic inflammatory Disease (CPID)of blood stagnate and deficiency of the kidney and the effect on inflammatory cytokines of the experimental model rats and probing the mechanism of action . Methods ：71 patients are divided into two groups at random. 35 patients in observation group are treated with Pen Qiangyan Granule. 36 patients in control group are treated with Pen Yanjing Granule . The related items are measured before and after the treatment. 70 rats are randomly divided into seven groups. After the histomorphological changes of the rats uteri observed, we determine the concentration of IL-6 and IL-4 in serum of rats in each group . Results ：The clinical study shows that the efficiency of the treatment group is 85.71%, significantly better than the control group (P 0.05). After treatment, the comprehensive integ