益气散结汤联合免疫干预治疗聚合性痤疮的实验研究和临床观察.pdfVIP

提 要 目的：完成对益气散结汤联合免疫干预治疗聚合性痤疮的实验研究及临床观察， 探讨聚合性痤疮的发病机理，以及中药益气散结法治疗聚合性痤疮的理论机理。方法： 将60例患者随机分为3组，分别为Ⅰ组为美满霉素组+胸腺肽注射组，Ⅱ组为益气散 结汤+美满霉素组，Ⅲ组为益气散结汤+美满霉素+胸腺肽注射组。通过抗炎及免疫试 验，检测中药方剂对致敏小鼠模型的抗炎作用，以及对其免疫功能的影响。结果：动 物实验显示，益气散结汤可抑制 DNCB 致炎小鼠的迟发型超敏反应，并提高其免疫功 能；益气散结汤可抑制二甲苯致炎小鼠的速发型超敏反应；临床观察，聚合性痤疮的 发病与免疫功能有关系；三组疗效依次是益气散结汤+美满霉素+胸腺肽注射组＞益气 散结汤+美满霉素组＞为美满霉素组+胸腺肽注射组；结论：益气散结汤具有明显的抗 炎及免疫调节作用，治疗聚合性痤疮疗效显著。 关键词 益气散结法；聚合性痤疮；抗炎试验；免疫干预 Experimental and Clinical study on the Treatment of Acne Conglobata Using Yiqi Sanjie soup United Immune Intervention Ways Specialty：The Surgery of TCM Author ：Chen Tian-li Tutor ：Zhou Chun-ying Abstract Objective：Completion of the Yiqi Sanjie soup united immune intervention in the treatment of acne experimental study and clinical observation to explore the pathogenesis of acne conglobata, as well as the treatment mechanism of Chinese medicine Yiqi Sanjie soup treating acne conglobata. Methods ：Through anti-inflammatory and immune tests, Detect chinese medicine Yiqi Sanjie soup of sensitized mouse model of anti-inflammatory effects, as well as their immune function. Clinical observation, 108 cases of patients will be randomly divided into 3 groups, namely group Ⅰminocycline Group + thymosin injection group, Ⅱ group was chinese medicine Yiqi Sanjie soup + minocycline group, Ⅲgroup was chinese medicine Yiqi Sanjie soup + minocycline + thymosin injection group. Rsults ： Through anti-inflammatory and immune experiment found that Yiqi Sanjie soup of proinflammatory DNCB inhibited the delayed-type hypersensitivity in mouse, and improve their immune function; Yiqi Sanjie soup inhibited xylene-induced inflammation in mouse Immediate hypersensitivity; clinical observations, the incidence of acne co