益气活血法对急性冠脉综合征的疗效探究.pdfVIP

提 要 目的：观察益气活血法配合西药对急性冠脉综合征的疗效，并探讨其作用机制。 方法：临床研究中采用随机、对照的研究方法，将急性冠脉综合征患者 60 例随机分 为治疗组和对照组两组，治疗组 30 例，对照组 30 例。治疗组予常规西药加中药配伍 治疗（黄芪注射液、丹参注射液），对照组予常规西药。4 周为 1 疗程。观察治疗前 后两组的临床症状改善，中医症状改善，心电图的改善情况，血脂、C 反应蛋白 （hs-CRP ）、一氧化氮（NO ）及内皮素（ET ）等指标变化。结果：临床试验表明， 益气活血法可改善症状，改善心功能，调节血管活性物质，减轻炎症反应，降低血脂 及 hs-CRP 。统计表明，治疗组疗效明显优于对照组(P0.01) ，治疗组临床疗效及心 电图有效率分别为 93.3%，76.7%，明显高于对照组 80.0%，56.7%，有显著性差异 (P0.05) ；治疗组与对照组治疗前后血脂各项指标及血清 hs-CRP 各项参数比较有显 著性差异(治疗组 P0.01 对照组 P0.05) ，两组比较，治疗组治疗后 TC，TG， LDL-C 、 hS-CRP 含量明显低于对照组，差异具有统计学意义(P0.05) ；治疗组ET 水平下降， NO 水平升高，与对照组及治疗前比较差异有显著性 (P0.05) 。结论：益气活血法具 有益气通脉、活血化瘀的功效，能改善症状，改善血管内皮功能，降低血脂，减轻炎 症反应，从而起到稳定冠状动脉粥样硬化斑块的作用；配合西药治疗冠脉综合征，疗 效明显优于单纯应用西药。 关键词 益气活血法；急性冠脉综合征；不稳定斑块；炎症反应 Clinical Study on ACS Disease by The Method of Supplementing QI and Activating Blood Circulation Speciality:Internal Medicine of Integrated TCM and Western Author :Li Shuqing Tutor:Prof. Meng Zhaoyang Abstract Objective: To observe the therapeutic effect and discuss the mechanism of the Method of Supplementing Qi and Activating Blood Circulation combined with Western medicine on acute coronary syndrome (ACS) disease. Methods:60 patients with ACS were randomly divided into the control group and treatment group with 30 cases in each group. The patients of the control group were treated with routine medicine and those of the treatment group were added with traditional Chinese medicine (TCM) HuangQi injection combined with Danshen injection At the same time ， conventional western medical therapy was given to the control group.4 week as one therapeutic course. The changes of clinic symptoms and signs of TCM，