益气活血祛风法治疗不稳定型心绞痛的临床和实验研究.pdfVIP

提 要 目的：从临床、实验研究两方面对不稳定型心绞痛（UA）的病因病机、治疗方药 进行较为系统地探讨。确立了益气活血祛风的治疗方法，并以此拟方益心活血祛风饮， 旨在观察益气活血祛风法治疗不稳定型心绞痛的临床疗效并探讨其作用机制。方法： 临床观察将60例患者随机分为以西医常规治疗加益心活血祛风饮的治疗组（30例）， 以西医常规治疗的对照组（30例）。观察其临床症状、心电图、血液流变学、CD62p、 CD63等指标。动物实验采用Wistar大鼠70只，其中60只成功复制垂体后叶素致急 性心肌缺血模型，观察益心活血祛风饮对其心电图、SOD、MDA、ET、TXB 的影响。结 2 果：临床观察表明，治疗组在改善患者临床症状，调脂、降低血液粘度和血小板活化 等方面均优于对照组(P0.05)。动物实验研究表明，益心活血祛风饮可明显改善急性 心肌缺血大鼠心电图缺血性改变,降低 MDA、ET、TXB ，提高 NO 和 SOD 水平。结论： 2 益心活血祛风饮具有明显的临床治疗作用，其能保护血管内皮功能,清除氧自由基， 抑制脂质过氧化，降低血液粘度和血小板活化，从而起到抗动脉粥样硬化形成，稳定 动脉粥样斑块的作用。 关键词 益气活血祛风法；不稳定型心绞痛；胸痹心痛；益心活血祛风饮 The Study of Clinical and experimental research to supplement qi and promote blood circulation and dispel wind in the treatment of unstable angina Spacilicity: cardioangiology of combination of TCM and west medicine Author: ZhangYuenan Tutor: DuanXuezhong Abstract Objective: Systematically explores the etiological factors and therapeutic methods of unstable angina pectoris (UA) in active phase from both experimental and clinical aspects. We established the therapeutic methods was:supplementing qi and promoting blood circulation and dispelling wind.Based on that, we developed a concrete treatment approach Yixinhuoxuequfeng Yin which aiming to study the efficacy and mechanism of this approach.Methods: In the clinical study,sixty patients were randomly divided into the treatment group(30 cases) and the control group(30 cases). Conventional Western medical therapy was given to both groups.At the same time,the treatment group received Yixinhuoxuequfeng Yin.We studied the clinical symptoms,ECG,hemorrh