益气化浊调血方治疗慢性肾脏病3～4期的临床探究.pdfVIP

提 要 目的：通过临床观察益气化浊调血方治疗慢性肾脏病 3～4 期气血亏虚，浊瘀阻 滞证的有效性、安全性，从而为延缓慢性肾脏病的进展提供新的思路。方法：采用随 机、开放、阳性药物平行对照临床研究方法，观察慢性肾脏病早、中期患者 50 例， 分为治疗组与对照组各 25 例，两组均采用饮食控制与对症治疗，治疗组在此基础上 予益气化浊调血方加减，水煎服，日一剂；对照组在此基础上口服尿毒清颗粒，每日 早、中、晚各 5 克(l 袋)，睡前 10 克(2 袋)。疗程 8 周。结果：(1)肾功能比较：治 疗 8 周后，两组 Scr 均有上升，Ccr 均有下降，但治疗组治疗前后无显著性差异，P 均大于 0.05；而对照组治疗前后有显著性差异（P＜0.05）。说明治疗组在稳定肾功 能方面优于对照组。(2)血红蛋白比较：治疗组治疗后血红蛋白较治疗前有明显提升， 有显著性差异(P﹤0.05)；而对照组治疗前后血红蛋白比较无显著性差异(P＞0.05)； 治疗组与对照组比较，治疗组Hb升高更明显，与对照组相比有显著性差异(P﹤0.05)。 说明治疗组在改善肾性贫血方面优于对照组。(3)中医证候疗效比较：治疗后 8 周两 组病人中医证候总积分与治疗前比较均有显著性差异(P0.05)，且治疗组中医证候总 积分明显低于对照组(P0.05)。(4) 综合疗效比较：在治疗8周时，两组病人的综合 疗效相当，无统计学差异 (P0.05)。 结论: 益气化浊调血方治疗慢性肾脏病早、中期的临床疗效与尿毒清颗粒相似。 关键词：慢性肾脏病；益气化浊调血方；气血亏虚、浊瘀阻滞证 PE gasification turbidity adjustable for treatment of chronic kidney disease blood 3 ~ 4 phase of clinical research Speciality: Research on the Urinary system treatment with TCM Author: Chenglong Guo Tutor: Prof. Anqin Jiao Abstract Objective: through clinical research observation profit gasification turbidity adjustable for treatment of chronic kidney disease blood 3 ~ 4 period, qi deficiency and blood stasis syndrome of block turbid, efficacy, safety to delay the progress of chronic kidney disease and provide new ideas. Methods: a randomized, open and positive drug parallel controlled clinical research methods. Chronic kidney disease, early in treatment group and control group mid-term: each 25 cases, diet and symptomatic treatment in treatment group, on the basis of PE gasification turbidity adjustable blood square to add and subtract, water frying clothing, day one agent; The control group oral urine poisonous clear particles, early, middle and late daily of 5 grams (l bags), bedtime 10 grams (2 bags). Treatment 8 weeks. Results : (1) renal comparison: treatment after eight weeks, two groups of Scr are rising, Ccr all have declined,