益气养阴解毒方联合化疗治疗急性白血病对患者血清VEGF、LDH水平的影响和临床观察.pdfVIP

提 要 目的：研究益气养阴解毒方联合化疗治疗急性 白血病对患者血清 VEGF、LDH 水平 的影响及临床观察。 方法：2011 年 3 月至 2012 年 1 月收集于我院及齐鲁医院初诊的急性 白血病患者 40 例，随机分为中药组和对照组，每组 20 例，中药组给予常规化疗方案加益气养阴 解毒方汤剂辅助治疗，对照组给予常规化疗方案，观察治疗前后患者血清 VEGF 及 LDH 水平变化及中医证候疗效。 结果：治疗结束后，中药组患者血清 VEGF、LDH 水平明显低于对照组，与对照组 比较有显著性差异 （P0.05）；中药组总缓解率为 80%，与对照组 (70%)比较有显著性 差异 （P0.05）；中药组中医证候疗效 （80%）显著优于对照组 （45%），与对照组比较 有显著性差异。 结论：益气养阴解毒方联合化疗治疗急性 白血病可显著降低患者血清 VEGF、LDH 水平，明显改善患者气阴两虚症状，提高缓解率。 关键词 益气养阴解毒方；急性 白血病；VEGF；LDH；中医证候疗效 Influence to V EG F、LD H in A Ls Serum of A djutant Therapy of Y iQ i YangY in JieD u Prescription A nd C linical O bservation Speciality： Internal M edicine of TCM A uthor： zheng w ei Tutor：Prof.zhou yan-feng A bstract O bjective：To observe the influence to V EG F、LD H in A Ls serum of adjutant therapy of Y iQ i YangY in JieD u Prescription and clinical observation M ethods：40 A L cases w ere divided into Chinese traditional m edicine group and the control group random ly, each group of 20 cases. The chinese traditional m edicine group w ere treated w ith conventional chem otherapy plus yiqi yangyin jiedu decoction，the other group only used conventional chem otherapy. O bserve the changes of V EG F、LD H in A L ’s serum and syndrom es integral before and after the treatm ent. R esults：A fter the treatm ent ,w e found conventional chem otherapy plus yiqi yangyin jiedu decoction can reduce the level of V EG F and LD H in A L’s serum , there w as significant difference am ong groups （P0.05）. C om pared the total rem ission rate and the syndrom es integral, w e find that the treatm ent group w ere higher than the control group, there w ere predom inant difference betw een the tw o groups （P0.05）. C onclusions：Conventional chem otherapy plus yiqi yangyin jiedu decoction can reduce the level of V EG F and LD H in A L ’s serum , significantly im prove patients w it