芪术运脾汤治疗气虚血瘀型功能性便秘的临床探究.pdf

提 要 目的：观察芪术运脾汤治疗气虚血瘀型功能性便秘的临床疗效，并 探讨其治疗功能性便秘的作用机理。 方法：临床选择符合纳入标准的功能性便秘患者60 例，随机分为治 疗组（30 例）和对照组（30 例），治疗组予以自拟芪术运脾汤加减治疗， 对照组予以胃肠复元膏，两周一疗程，治疗两疗程。治疗结束后,观察两 组患者治疗前后临床症状、中医证候等改善情况，进行疗效评价；同时 行血、尿、大便常规及心、肝、肾功能等安全性检测。 结果：临床研究显示，在临床症状疗效方面，治疗组在消除或改善 粪便性质、排便间隔时间、排便费力、体倦乏力等症状上，疗效优于对 照组（P﹤0.05）；治疗组在中医证候疗效方面，治疗组治愈15 例，显效 10 例，有效 3 例，痊愈+显效率为 83.33%，总有效率为 93.33%；对照组 临床痊愈 9 例，显效8 例，有效4 例，痊愈+显效率为 56.67%，总有效率 为 70.00%；治疗组显著优于对照组（痊愈+显效率及总有效率比较 P0.05）；治疗组在中医症状总积分改善方面，疗效优于对照组（P0.05）。 治疗组疗程结束时，血、尿、大便常规及心、肝、肾功能等检测均未发 生不良反应。 结论:芪术运脾汤是治疗气虚血瘀型功能性便秘的有效方药，其机理 可能与调节胃肠运动、调节胃肠激素的水平、改善微循环、抗炎，调节 免疫功能等有关。 关键词 功能性便秘；气虚血瘀；芪术运脾汤 Clinical study of QiZhuYunPiTang in Treating Functional Constipation with Qi Deficiency and Blood Stasis Syndrome Specialty :TCM internal Medicine Author: Guo Liang Tutor: Director of Physicians Liu Dong Mei Abstract Objective: To assess the efficacy and mechanism of QiZhuYunPiTang in the treatment of FC with Qi deficiency and blood stasis syndrome. Methods: 60 patients were devided randomly into two groups.30 patinets were received QiZhuYunPiTang as the study group,and 30 patinets were received WeiChangFuYuanGao capsules as the control group. After 4 weeks treatment,the changes of clinic symptom were analyzed. Results: In the efficacy of TCM，the treatment group was better than control group (p0.05). After one course of treatment,significant difference was apparent in the clinical effects:In the treatment group，15 cases recovered and 10 cases significantly improved，(thus the effectual rate is 83.33%),3 cases improved. The total effective rate in the treatment group is 93.