胱抑素c与老年2型糖尿病患者认知功能障碍相关 - 中华老年多器官 .doc

·临床研究· 胱抑素C与老年2型糖尿病患者认知功能障碍相关 章晓燕1，钟 远1，苗 雅1，燕 虹1，沈 静2，胡艳云2，包玉倩2，刘 芳2*，贾伟平2 （上海交通大学附属第六人民医院：1老年病科；2内分泌代谢科，上海市糖尿病临床医学中心，上海市糖尿病研究所，上海市重中之重代谢病临床医学中心，上海 200233） 【摘 要】目的 探讨血清胱抑素C（Cys C）水平与老年2型糖尿病患者认知功能障碍的相关性。方法 选取老年2型糖尿病患者352例，其中认知功能正常组（NC组）146例、轻度认知功能障碍组（MCI组）112例，阿尔茨海默病组（AD组）94例。采用简易智能状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）评定患者认知功能。检测所有患者血糖、血脂、Cys C水平、肝肾功能等，比较三组间临床特征及Cys C水平差异。结果 三组间血清Cys C水平差异具有统计学意义（均P＜0.05）。NC、MCI、AD组血清Cys C水平依次升高。相关分析表明，血清Cys C水平与年龄、糖尿病病程、甘油三酯（TG）、血肌酐（Cr）、糖化血红蛋白（HbA1c）呈正相关（r＝＝((0.237、(0.185，均P＜0.05）。logistic回归分析显示Cys C（P＝＝＝＝＝＝＝＝R962.1; R587.1; R592 【文献标识码】 A 【DOI】 ? Serum Level of Cystatin C is associated with cognitive impairment in elderly type 2 diabetic patients ZHANG Xiao-Yan1, ZHONG Yuan1, MIAO Ya1, YAN Hong1, SHEN Jing2, HU Yan-Yun2, BAO Yu-Qian2, LIU Fang2*, JIA Wei-Ping2 (1Department of Geriatrics, 2Department of Endocrinology Metabolism, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Clinical Center of Metabolic Disease, Shanghai 200233, China) 【Abstract】 Objective To investigate the relationship between serum cystatin C level and cognitive impairment in type 2 diabetic patients. Methods A total of 352 type 2 diabetic patients were included in this cross-sectional study, including 146 cases of normal cognition group (NC), 112 cases of mild cognitive impairment group (MCI), 94 cases of Alzhermer’s disease group (AD). Mini-mental status examination (MMSE) and Montreal cognitive assessment (MoCA) were applied to evaluate their cognitive function. Their clinical and biochemical characteristics and serum Cystatin C were tested. Results There were significant differences in serum cystatin C level among the three groups. The patients in AD group had highest serum cystatin C level, the patients in NC group had the lowest cystatin C. Spearman correlation analysis showed that Cystatin C level was positively correlated with age, durati