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· · 药学学报 Acta Pharmaceutica Sinica 20 16, 51 ( 1): 29 32 29 噬对抗肿瘤药物毒性的调控作用研究进展 娄小娥, 朱 怡, 何俏军* (浙江大学药理毒理研究所, 浙江省抗肿瘤 物临床前研究重点实验室, 浙江大学 学院, 浙江 杭州 3 10058) 摘要: 自噬是调节真核细胞生长、死亡、能量代谢的重要生物学机制。大量证据表明自噬参与多种抗肿瘤 药物所导致的毒性, 特别与心脏、肝脏及神经的损伤关系密切, 目前对于自噬的调控作用是抗肿瘤药物毒性研究 领域的热点。由于自噬对于心脏、肝脏和神经的功能是一把双刃剑, 因此自噬对抗肿瘤 物毒性的调控作用是 极其复杂的。这里作者将介绍自噬的基本概念并总结目前自噬对抗肿瘤药物毒性的调控作用。通过梳理这方面 的研究成果将有助于抗肿瘤 物毒性的基础研究, 并为抗肿瘤药物的毒性提供潜在的解决方案。 关键词: 自噬; 抗肿瘤药物; 心脏毒性; 肝脏毒性; 神经毒性 中图分类号: R966 文献标识码: A 文章编号: 0513-4870 (20 16) 0 1-0029-04 Study on the regulation of autophagy against anticancer drugs toxicity * LOU Xiao-e, ZHU Yi, HE Qiao-j un (Ins titute of Pharmacology and Toxicology, Zhejiang Province Key L aboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China ) Abstract : Autophagy is a crucial biological process in eukaryotes, which is involved in cell growth, survival and energy metabolism. It has been confirmed that autophagy mediates toxicity of anticancer drugs, especially in heart, liver and neuron. It is important to understand the function and mechanism of autophagy in anticancer drugs-induced toxicity. Given that autophagy is a double-edged sword in the maintenance of the function of heart, liver and neuron, the autophagy-mediated toxicity are very complicated in the body. We provide a review on the concept of autophagy and current status