口腔 药理学0501（Oral pharmacology 0501）.docVIP

口腔 药理学0501（Oral pharmacology 0501） Section 1 antihypertensive drugs Angiotensin II receptor blocking drugs have a short clinical application time, but because of its many advantages, there are more and more clinical applications, so they are commonly referred to as antihypertensive drugs after they are placed in the four categories of drugs. Nifedipine (1) pharmacological action - calcium channel antagonists. Effect of nifedipine on the cell membrane of L- type calcium channel, through the inhibition of calcium from outside the cell into the cell, and the intracellular calcium concentration decreased, resulting in dilation of arterioles, total peripheral vascular resistance decreased while lowering blood pressure. Side effects: peripheral blood vessels dilate and cause sympathetic activity to reflex and cause reflex heart rate to accelerate. (two) clinical application Nifedipine has a hypotensive effect on mild, moderate and severe hypertension, and is also suitable for patients with angina pectoris or kidney disease, diabetes, asthma, hyperlipidemia and malignant hypertension. Slow release tablets are now recommended to alleviate the increased reflex activity induced by rapid hypotension. Two, Kato Pury (I) pharmacological action Kato Pury can inhibit the activity of ACE, reduce the production of angiotensin II (Ang II) and reduce the degradation of bradykinin, dilate blood vessels and lower blood pressure. Mild to moderate hypotensive effects can reduce peripheral vascular resistance and increase renal blood flow without increasing reflex heart rate. (two) clinical application Applicable to all types of hypertension. Currently one of the first-line drugs for antihypertensive treatment. About 60% to 70% patients can control the blood pressure at an ideal level by using this product alone, and 95% of them are effective with diuretics. It is especially suitable for patients with diabetes and insulin resistance, left ventricular hypertrophy, heart failure and acute my