PLGA-PCL多聚物单丝生物缝线的制备及力学特性 - 第三军医大学学报.DOC

PLGA-PCL多聚物单丝生物缝线的制备及力学特性研究 陈翔宇 任小宝（400038 重庆，第三军医大学西南医院急救创伤中心） [摘要]目的研发一种新型的生物缝线，并检测其力学特性。探讨通过控制生物缝线基质的成分比来控制生物缝线的力学特性的可能性。方法PLGA及PCL不同比例预混，采用热熔纺丝和冷拔丝技术，制备多聚物单丝。以商用铬制羊肠线作为参照物，检测多聚物单丝的抗张强度、可拉伸率、非张力条件下的可塑性。结果我们成功制备了四种PLGA/PCL复合物单丝，分别为S1、S2、S3、S4。多聚物单丝的直径为-314μm，S2、S3、S4的抗张强度超过美国药典对同类手术缝线的技术要求，在一定范围内增加PCL的含量可以增加多聚物单丝的抗张强度、增加其弹性，以及增加其非张力条件下的可塑性。结论 PLGA-PCL多聚物单丝生物缝线PLGA-PCL多聚物单丝生物缝线Preparation of Complex PLGA-PCL Monofilament Bio-sutures and Their Mechanical Properties Xiangyu Chen Xiaobao Ren （400038 Chongqing， Trauma Center of SouthWest Hospital of The Third Military Medical University） [Abstracts] Objective To develope a complex monofilament of PLGA blended PCL as a novel bio-suture, study its mechanical properties. To evaluate the possibility of controlling the mechanical properties of bio-suture by changing its composition ratio. Methods PLGA-PCL monofilaments were prepared by using melt-spinning cold-drawing technique. Its mechanical properties were evaluated by an universal test machine. Results Four complex polymer monofilaments of S1, S2, S3 and S4 were successfully produced at different PLGA/PCL ratio. The average diameter of those monofilaments ranged from 281um to 314um。Three complex monofilaments (S2, S3, S4) showed strong tensile strength，exceeding the base-level requirement of 26.3 N for sutures sized 2–0 (0.300-0.339 mm) in United States Pharmacopeia (USP). The mechanical properties of those complex monofilaments were controllably changed by ratio of PLGA and PCL. Conclusions Complex PLGA-PCL monofilament bio-sutures showed expectable mechanical properties, exceeding the requirement of USP. It’s possible that the mechanical properties of complex PLGA-PCL monofilament bio-sutures could be controllably changed by changing the ratio PCL within a certain range. [Key Words] PLGA；PCL；Bio-suture 缝线广泛的应用于外科手术中，主要分为可吸收缝线和不可吸收缝线。可吸收缝线由于其可降解性及良好的组织相容性已经被广泛的使用，并逐渐取代不可吸收缝线。 铬制羊肠线是最早被使用的可吸收缝线，近年来，通过化学合成的方法，越来越多的可吸收缝线应用于临床，如Dexon、PDSII、MAXON和Vicky。羊肠线的基材是异种动物胶