浙江大学医学免疫学经典免疫13.超敏反应.pptVIP

Hypersensitivity (超敏反应);Hypersensitivity Some immune responses can give rise to an excessive or inappropriate reaction, resulting in significant tissue damage or even death. The classification: type I~IV;Robin Coombs 1921 - 2006;Types of hypersensitivity diseases. In the four major types of hypersensitivity reactions, different immune effector mechanisms cause tissue injury and disease;Type I hypersensitivity (immediate hypersensitivity);初次注射 海葵毒素;Carl Prausnitz-Giles 1876-1963;Prausnitz-Kustner test --- “reagin”;痔整挡冬纂颓爵熬婚救仕伯瞥偶途括夫赵在妊茨凡亢夸逻价汲南快岿黍苦浙江大学医学免疫学经典免疫13.超敏反应浙江大学医学免疫学经典免疫13.超敏反应;Kimishige Ishizaka（1925-）and Teruka Ishizaka;Characteristics of Type I hypersensitivity;Mediated by IgE antibodies Typical examples include polymorphisms of the promoter region for IL-4 and polymorphism of the gene for IL-5, either of which can directly influence the IgE production to allergens. ‘atopy’: An IgE-dependent allergy often arising from exposure to an unknown Ag.;Allergen is an antigen that gives rise to immediate hypersensitivity. protein or chemicals For example: pollen, house dust mite, animal hair, dander, some foods, foreign serum, drugs. Allergin is a specific IgE that gives rise to immediate hypersensitivity.;Allergen;IgE分子及其受体;The majority of humans mount significant IgE response only as a defense against parasitic infections. After an individual has been exposed to a parasite, serum IgE levels increase and remain high until the parasite is successfully cleared from the body. Atopic individuals allow non-parasitic Ags to stimulate inappropriate IgE production, leading to type I hypersensitivity.;Most allergic IgE response occur on mucous membrane surfaces in response to allergens that enter the body by either inhalation or ingestion.; mast cells, basophils and eosinophils;Mast cells Basophils Eosinophils Mediators released by eosinophil: eosinophil cationic protein eosinophil peroxidase LTs, PAF