根据蛋白质互作网络预测乳腺癌相关蛋白质细致功能.pdfVIP

HEREDITAS (Beijing) 2007 9 29(9): 1061 ―1066 ISSN 0253-9772 研究报告 DOI: 10.1360/yc-007-1061 1 1 1,2 1 1 1 1 王靖 , 李彦辉 , 郭政 , 朱晶 , 马文财 , 彭春方 , 刘庆 1. , 150086; 2. , 610054 乳腺癌是最为常见的恶性肿瘤之一。已有的关于乳腺癌相关蛋白质的功能注释比较宽泛, 制约了乳腺癌 的后续研究工作。对于已知部分功能的乳腺癌相关蛋白质, 提出了一种结合Gene Ontology 功能先验知识和蛋 白质互作的方法, 通过构建功能特异的局部相互作用网络来预测乳腺癌相关蛋白质的细致功能。结果显示该方 法能够以很高的精确率为乳腺癌相关蛋白质预测更为精细的功能。预测的相关蛋白质的功能对于指导实验研究 乳腺癌的分子机制具有重要的价值。 : 乳腺癌; 蛋白质功能; 预测; 互作网络; 基因本体 Finding finer functions for proteins related to breast cancer based on protein interaction network 1 1 1,2 1 1 1 WANG Jing , LI Yan-Hui , GUO Zheng , ZHU Jing , MA Wen-Cai , PENG Chun-Fang , LIU Qing1 1. Department of Bioinformatics, Pharmacology and Bio-pharmaceutical Key Laboratory of Heilongjiang Province and State, Harbin Medi- cal University, Harbin 150086, China; 2. School of Life Science and Bioinformatics Centre, University of Electronic Science and Technology of China, Chengdu 610054, China Abstract: Breast cancer is one of the most common malignant tumours. However, the existing functional knowledge about the proteins related to the breast cancer is too general to promote the following study. To find their finer functions, we sug- gest using the function-specific interaction sub-networks by integrating the functional knowledge of Gene Ontology and the protein-protein interaction network. The results show that the proposed approach is able to reliably find finer functions for these proteins with high precision. The predicted finer functions are highly valuable