il 18基因多态性与原发性干燥综合征的相关性（The correlation between il 18 gene polymorphism and primary dry syndrome）.docVIP

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il 18基因多态性与原发性干燥综合征的相关性（The correlation between il 18 gene polymorphism and primary dry syndrome）.doc

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il 18基因多态性与原发性干燥综合征的相关性（The correlation between il 18 gene polymorphism and primary dry syndrome）

il 18基因多态性与原发性干燥综合征的相关性（The correlation between il 18 gene polymorphism and primary dry syndrome） Il? The correlation between genetic polymorphism and primary dry syndrome Article: / Author: yan liping, yan liping, miao miao, li [abstract] objective to explore il? 18 genes? 137 g/c,? The correlation of 607c/a site polymorphism and serum level with primary dryness syndrome. Methods: the DNA of white blood cells was extracted and polymerase chain reaction was used. The restriction fragment length polymorphism technique was used to detect 28 patients with idiopathic dry syndrome and 52 healthy controls, il. 18 genes? 607 c/a,? 137g/c site polymorphism, enzyme-linked immunosorbent (elisa) method for detection of two groups of serum il? 18 levels. Two groups of il? 18 genes? 137 g/c,? There was no significant difference in genotype frequency and allele frequency of 607c/a loci (p 0.05). Primary dry syndrome group serum il? The level of 18 was significantly lower than that of the healthy control group, and the difference was significant (t = 24.06, p 0.001). Serum il of different genotypes in primary dry syndrome group There was no significant difference in level 18 (p 0.05). Conclusion serum il? Level 18 expression reduction may be a trigger for primary dry syndrome. [key words] interleukin 18; Genotype; Gene frequency; Primary dry syndrome Abstract objective to investigate the association of polymorphisms of? 607 c/a,? 137 g/c promoters of il? 18 gene and its serum level with primary sjogrens syndrome. The methods the DNA of white blood cells were extracted from the subjects, polymerase chain reaction? Restriction fragment length polymorphism (PCR? RFLP) method was applied to detect polymorphisms of? 607 c/a,? 137 g/c promoters of il? 18 gene in 28 patients with primary sjogrens syndrome (group a) and 52 healthy controls (group b); Serum il? Measured in both groups by elisa. Results there was no differences in il. 18 genotype frequency and allele frequency at position?