美罗凯专家杨金波教授个人简介.docVIP

美罗凯专家杨金波教授个人简介 杨金波兰州大学生命科学学院萃英特聘教授、博士生导师。美国克利夫兰癌症研究中心（Cleveland Cancer Research Center of USA.）首席科学家。2001年获得中国科学院上海生物化学研究所生物化学与分子生物学专业博士学位。历任美国 Lerner Research Institute, The Cleveland Clinic Foundation, 博士后(Postdoctoral Research Fellow) (2001 - 2004 年)、研究员 (Research Associate Staff) (2005 - 2006 年)、项目科学家 (Project Staff) (2007 年)、客座研究员 (Adjunct Staff) (2008 年)、顾问委员 (Consultant Staff) (2009年 - )。主要研究方向为肿瘤相关的信号转导与分子机制，重点研究 JAK-STATs、NF(B等信号转导关键分子到调控机制及其与肿瘤形成的关系、肿瘤耐药性关键分子的发现与分子机制、STATs、NF(B、IRFs 等转录因子的生物学功能、翻译后加工修饰与基因表达调控的分子机制。承担和主持多项科技部国际合作重点项目、自然科学基金项目和省市重点。 论文专著 (*) Jing Nan, Yuping Du, Xing Chen, Qifeng Bai, Yuxin Wang, Xinxin Zhang, Ning Zhu, Jing Zhang, Jianwen Hou, Qin Wang and Jinbo Yang*. TPCA-1 is a direct dual inhibitor of STAT3 and NFκB and regresses mutant EGFR associated human non-small cell lung cancers. Molecular Cancer Therapeutics. (2014); 13(3) Yuxin Wang, Anette H. H. van Boxel-Dezaire, HyeonJoo Cheon,?Jinbo Yang*? George R. Stark*. STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor. Proc Natl Acad Sci USA. (2013); 110(42):16975-80. Xing Chen, Yuping Du, Jing nan, Xinxin Zhang, Xiaodong Qin, Yuxin Wang, Jianwen Hou, Qin Wang Jinbo Yang*. Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells.?PLoS One.?(2013) 8, e63697. Jianxin He, Jie Shi, Ximing Xu, Wenhua Zhang, Yuxin Wang, Xing Chen, Yuping Du, Ning Zhu, Jing Zhang, Qin Wang* and?Jinbo Yang*. STAT3 mutations correlated with hyper-IgE syndrome lead to blockage of IL-6/STAT3 signalling pathway.?Journal of Biosciences.?(2012); 37(2):243-57. Qifeng Bai, Yulin Shen, Xiaojun Yao, Fang Wang, Yuping Du, Qin Wang, Nengzhi Jin, Jun Hai, Tiejun Hu*,?Jinbo Yang*. Modeling a New Water Channel That Allows SET9 to Dimethylate p53.?PloS ONE. (2011); 6(5):e19856 Olga A. Guryanova, Qiulian Wu, Lin Cheng, Justin D. Lathia, Zhi Huang,?Jinbo Yang, Jennifer MacSwords, Christine E. Eyler, Roger E. McLendon, John